biostudies-literatureUnknown22(1)Oz S<h4>Background</h4>The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated Ca_V1.2 channels, is of great physiological and pathophysiological importance. Stimulation of β-adrenergic receptors (βAR) activates protein kinase A (PKA) through separation of regulatory (PKAR) from catalytic (PKAC) subunits. Free PKAC phosphorylates the inhibitory protein Rad, leading to increased Ca²⁺ influx. In cardiomyocytes, the core subunit of Ca_V1.2, Ca_V1.2α₁, exists in two forms: full-length or truncated (lacking the distal C-terminus (dCT)). Signaling efficiency is believed to emanate from protein interactions within multimolecular complexes, such as anchoring PKA (via PKAR) to Ca_V1.2α<subBMC biology276https://www.ebi.ac.uk/biostudies/studies/S-EPMC11603854biostudies-literatureTripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca²⁺ channel may modulate its β-adrenergic regulation.PMC11603854Tsemakhovich VKatz MChomsky-Hecht OBertinetti DSholokh AKlussmann EDascal NPallien TVysochek LHirsch JASharon TTripathy DRSasson GSchulz-Christian MFecher-Trost CZuhlke KOz SKeren-Raifman TWatad BHerberg FWFlockerzi VWeiss SSubramaniam SfalseTripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca²⁺ channel may modulate its β-adrenergic regulation.<h4>Background</h4>The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated Ca_V1.2 channels, is of great physiological and pathophysiological importance. Stimulation of β-adrenergic receptors (βAR) activates protein kinase A (PKA) through separation of regulatory (PKAR) from catalytic (PKAC) subunits. Free PKAC phosphorylates the inhibitory protein Rad, leading to increased Ca²⁺ influx. In cardiomyocytes, the core subunit of Ca_V1.2, Ca_V1.2α₁, exists in two forms: full-length or truncated (lacking the distal C-terminus (dCT)). Signaling efficiency is believed to emanate from protein interactions within multimolecular complexes, such as anchoring PKA (via PKAR) to Ca_V1.2α<sub2024-01-01T00:00:00Z2024 Nov2026-06-01T06:43:48.524Z2025-04-04T00:45:22.162ZS-EPMC116038543960981210.1186/s12915-024-02076-9