{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rojo-Carrillo JJ"],"funding":["Centro de Investigación Biomédica en red de Enfermedades Raras, Spain","Fundación Española de Trombosis y Hemostasia","Instituto de Salud Carlos III","Ministerio de Ciencia e Innovación"],"pagination":["1148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11603882"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Protein-coding genes have been considered the functional part of the genome, although they represent only 2% of the genome. In contrast, more than 90% of the genome produces non-coding RNA (ncRNA), including antisense (AS) genes, a type of long non-coding genes (encoding transcripts > 200 nucleotides) located on the opposite strand of coding genes. Therefore, antisense RNA (asRNA) can be complementary to the counterpart sense RNA, supporting a regulatory role with potential pathogenic consequences, as their deregulation has been associated with cardiovascular disease, cancer, and diabetes.<h4>Results</h4>We performed an in-depth review of AS genes in Ensembl and evaluated the expression of AS genes in human liver by third-generation RNA sequencing methods. Currently, 165"],"journal":["BMC genomics"],"pubmed_title":["Landscape of antisense genes in the human genome and identification of new human hepatic antisense RNAs by long-read sequencing."],"pmcid":["PMC11603882"],"funding_grant_id":["RYC2021-031000-I","PI21/00174","Predoctoral fellowship","CB15/00055","PMP21/00052"],"pubmed_authors":["Padilla J","Llamas-Lopez M","Lozano ML","Garrido-Rodriguez P","de la Morena-Barrio ME","Rojo-Carrillo JJ","Ramos-Molina B","Cifuentes-Riquelme R","de la Morena-Barrio B","Corral J"],"additional_accession":[]},"is_claimable":false,"name":"Landscape of antisense genes in the human genome and identification of new human hepatic antisense RNAs by long-read sequencing.","description":"<h4>Background</h4>Protein-coding genes have been considered the functional part of the genome, although they represent only 2% of the genome. In contrast, more than 90% of the genome produces non-coding RNA (ncRNA), including antisense (AS) genes, a type of long non-coding genes (encoding transcripts > 200 nucleotides) located on the opposite strand of coding genes. Therefore, antisense RNA (asRNA) can be complementary to the counterpart sense RNA, supporting a regulatory role with potential pathogenic consequences, as their deregulation has been associated with cardiovascular disease, cancer, and diabetes.<h4>Results</h4>We performed an in-depth review of AS genes in Ensembl and evaluated the expression of AS genes in human liver by third-generation RNA sequencing methods. Currently, 165","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-02T05:02:31.991Z","creation":"2025-04-04T00:46:20.158Z"},"accession":"S-EPMC11603882","cross_references":{"pubmed":["39604851"],"doi":["10.1186/s12864-024-11017-3"]}}