{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(11)"],"submitter":["Morikawa T"],"pubmed_abstract":["<h4>Background</h4>The MitraClip (Abbott), a percutaneous edge-to-edge mitral valve (MV) repair device, is the only approved device in Japan for mitral transcatheter edge-to-edge repair (M-TEER) therapy to treat primary and secondary mitral regurgitation (MR). Outcomes of the fourth-generation M-TEER system, featuring independent grasping, improved clip deployment, and 4 clip sizes with wider and longer clip arms, have not been reported in Japan.<h4>Objectives</h4>This study evaluates the 1-year safety and effectiveness of the fourth-generation M-TEER system in Japan to treat MR in a contemporary, real-world setting.<h4>Methods</h4>EXPAND G4 is a prospective, single-arm, international, postmarket study. One-year outcomes from subjects treated in Japan include MR severity (assessed by an ec"],"journal":["JACC. Asia"],"pagination":["810-821"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11604470"],"repository":["biostudies-literature"],"pubmed_title":["1-Year Outcomes of Fourth-Generation Mitral Transcatheter Edge-to-Edge Repair in Japan From the EXPAND G4 Study."],"pmcid":["PMC11604470"],"pubmed_authors":["Morikawa T","Yamamoto M","Yagasaki H","von Bardeleben RS","Asami M","Asch FM","Ueno H","Dong M","Rodriguez E","Enta Y","Peterman K","Sakamoto T"],"additional_accession":[]},"is_claimable":false,"name":"1-Year Outcomes of Fourth-Generation Mitral Transcatheter Edge-to-Edge Repair in Japan From the EXPAND G4 Study.","description":"<h4>Background</h4>The MitraClip (Abbott), a percutaneous edge-to-edge mitral valve (MV) repair device, is the only approved device in Japan for mitral transcatheter edge-to-edge repair (M-TEER) therapy to treat primary and secondary mitral regurgitation (MR). Outcomes of the fourth-generation M-TEER system, featuring independent grasping, improved clip deployment, and 4 clip sizes with wider and longer clip arms, have not been reported in Japan.<h4>Objectives</h4>This study evaluates the 1-year safety and effectiveness of the fourth-generation M-TEER system in Japan to treat MR in a contemporary, real-world setting.<h4>Methods</h4>EXPAND G4 is a prospective, single-arm, international, postmarket study. One-year outcomes from subjects treated in Japan include MR severity (assessed by an ec","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-03T03:24:12.316Z","creation":"2025-04-04T01:23:47.624Z"},"accession":"S-EPMC11604470","cross_references":{"pubmed":["39619400"],"doi":["10.1016/j.jacasi.2024.08.003"]}}