{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rodriguez-Ubreva J"],"funding":["Wellcome Trust"],"pagination":["10344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11605083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency, marked by hypogammaglobulinemia, poor antibody responses, and increased infection susceptibility. The COVID-19 pandemic provided a unique opportunity to study the effects of prolonged viral infections on the immune responses of CVID patients. Here we use single-cell RNA-seq and spectral flow cytometry of peripheral blood samples before, during, and after SARS-CoV-2 infection showing that COVID-19 CVID patients display a persistent type I interferon signature at convalescence across immune compartments. Alterations in adaptive immunity include sustained activation of naïve B cells, increased CD21<sup>low</sup> B cells, impaired Th1 polarization, CD4<sup>+</sup> T central memory exhaustion, and increased "],"journal":["Nature communications"],"pubmed_title":["COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation."],"pmcid":["PMC11605083"],"funding_grant_id":["206194 and 108413/A/15/D"],"pubmed_authors":["de la Calle-Fabregat C","Prigmore E","Handfield LF","Hofmann M","Rodriguez-Ubreva J","Calafell-Segura J","Calvillo CL","Porter T","Vento-Tormo R","Hoo R","Warnatz K","Keller B","Ciudad L","Martin J","Andres-Leon E","Ballestar E","Godoy-Tena G","Decker A"],"additional_accession":[]},"is_claimable":false,"name":"COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation.","description":"Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency, marked by hypogammaglobulinemia, poor antibody responses, and increased infection susceptibility. The COVID-19 pandemic provided a unique opportunity to study the effects of prolonged viral infections on the immune responses of CVID patients. Here we use single-cell RNA-seq and spectral flow cytometry of peripheral blood samples before, during, and after SARS-CoV-2 infection showing that COVID-19 CVID patients display a persistent type I interferon signature at convalescence across immune compartments. Alterations in adaptive immunity include sustained activation of naïve B cells, increased CD21<sup>low</sup> B cells, impaired Th1 polarization, CD4<sup>+</sup> T central memory exhaustion, and increased ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-18T16:02:03.495Z","creation":"2025-04-07T02:59:12.452Z"},"accession":"S-EPMC11605083","cross_references":{"pubmed":["39609471"],"doi":["10.1038/s41467-024-54732-x"]}}