biostudies-literatureCampbell-Salome GNHLBI NIH HHSNational Institutes of HealthNational Heart Lung and Blood Institutee832-e843https://www.ebi.ac.uk/biostudies/studies/S-EPMC11606789biostudies-literatureUnknown18(5)<h4>Background</h4>Cascade testing can be highly effective in identifying individuals with familial hypercholesterolemia (FH) and help prevent atherosclerotic cardiovascular disease. The IMPACT-FH cascade testing program offered multiple optimized implementation strategies to improve FH cascade testing uptake.<h4>Objective</h4>Guided by the Conceptual Model of Implementation Research, this study assessed the IMPACT-FH cascade testing program's implementation outcomes.<h4>Methods</h4>Implementation outcomes were assessed qualitatively and quantitatively. Interviews were conducted with 33 IMPACT-FH program participants including 15 probands, 12 relatives, and 6 healthcare professionals (HCPs). Transcripts were analyzed using thematic analysis to investigate implementation outcomes. DescriptiJournal of clinical lipidologyUtilizing innovative implementation strategies for familial hypercholesterolemia: Implementation outcomes from the IMPACT-FH study.PMC11606789R01HL148246R01 HL148246Sturm ACMcGowan MPWalters NLMorgan KMRahm AKTricou EPJones LKCampbell-Salome GBrangan AGabriel JfalseUtilizing innovative implementation strategies for familial hypercholesterolemia: Implementation outcomes from the IMPACT-FH study.<h4>Background</h4>Cascade testing can be highly effective in identifying individuals with familial hypercholesterolemia (FH) and help prevent atherosclerotic cardiovascular disease. The IMPACT-FH cascade testing program offered multiple optimized implementation strategies to improve FH cascade testing uptake.<h4>Objective</h4>Guided by the Conceptual Model of Implementation Research, this study assessed the IMPACT-FH cascade testing program's implementation outcomes.<h4>Methods</h4>Implementation outcomes were assessed qualitatively and quantitatively. Interviews were conducted with 33 IMPACT-FH program participants including 15 probands, 12 relatives, and 6 healthcare professionals (HCPs). Transcripts were analyzed using thematic analysis to investigate implementation outcomes. Descripti2024-01-01T00:00:00Z2024 Sep-Oct2026-05-29T07:04:58.448Z2026-04-08T03:52:05.527ZS-EPMC116067893927876810.1016/j.jacl.2024.07.011