{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kharel K"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["dev202877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11607683"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["151(22)"],"pubmed_abstract":["Throughout metazoa, germ cells assemble RNA-protein organelles (germ granules). In Drosophila ovaries, perinuclear nuage forms in the nurse cells, while compositionally similar polar granules form in the oocyte. A similar system appears to exist in the distantly related (∼350 million years) wasp Nasonia, with some surprising divergences. Nuage is similarly formed in Nasonia, except that anterior nurse cells accumulate significantly more nuage, in association with high levels of DNA double-strand breaks, suggesting that increased transposon activity anteriorly is silenced by high nuage levels. In the oocyte, the germ plasm forms a single granule that is 40 times larger than a homologous Drosophila polar granule. While conserved germ granule proteins are recruited to the oosome, they show un"],"journal":["Development (Cambridge, England)"],"pubmed_title":["Dynamic protein assembly and architecture of the large solitary membraneless organelle during germline development in the wasp Nasonia vitripennis."],"pmcid":["PMC11607683"],"funding_grant_id":["P20 GM103436","P20GM103436","R01 GM129153","R01GM129153"],"pubmed_authors":["Schmidtke R","Arkov AL","Lynch JA","Tindell SJ","Alexander E","Kharel K","Kemph A"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic protein assembly and architecture of the large solitary membraneless organelle during germline development in the wasp Nasonia vitripennis.","description":"Throughout metazoa, germ cells assemble RNA-protein organelles (germ granules). In Drosophila ovaries, perinuclear nuage forms in the nurse cells, while compositionally similar polar granules form in the oocyte. A similar system appears to exist in the distantly related (∼350 million years) wasp Nasonia, with some surprising divergences. Nuage is similarly formed in Nasonia, except that anterior nurse cells accumulate significantly more nuage, in association with high levels of DNA double-strand breaks, suggesting that increased transposon activity anteriorly is silenced by high nuage levels. In the oocyte, the germ plasm forms a single granule that is 40 times larger than a homologous Drosophila polar granule. While conserved germ granule proteins are recruited to the oosome, they show un","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-10T05:01:15.703Z","creation":"2026-06-10T03:07:12.51Z"},"accession":"S-EPMC11607683","cross_references":{"pubmed":["39465418"],"doi":["10.1242/dev.202877"]}}