{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31"],"submitter":["Zhao Y"],"pubmed_abstract":["<h4>Objectives</h4>Human cancer is considered to be an important cause of death worldwide. Polypyrimidine tract binding protein 1 (PTBP1) is emerging as a powerful pro-oncogenic factor in bladder and liver cancer; however, no pan-cancer analysis is presently available. Our study aimed to explore PTBP1 expression profiles, prognostic immunological value, and biological functions across various cancers.<h4>Methods</h4>We conducted a comprehensive analysis using multi-omics bioinformatics from public databases, including TIMER, GEPIA2, ProteinAtlas, Kaplan-Meier Plotter, PrognoScan, cBioPortal, STRING, ENCORI, TargetScan, and DAVID.<h4>Results</h4>We found that PTBP1 was overexpressed across multiple cancer types. qRT-PCR results demonstrated that the PTBP1 mRNA was significantly up-regulated"],"journal":["Cancer control : journal of the Moffitt Cancer Center"],"pagination":["10732748241302865"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11607764"],"repository":["biostudies-literature"],"pubmed_title":["Pan-Cancer Analysis of PTBP1 to Identify it as a Prognostic and Immunological Biomarker."],"pmcid":["PMC11607764"],"pubmed_authors":["Xia J","Dong H","Hu Z","Mao Q","Zhu L","He H","Liao W","Xia Q","Weng Z","Wang Y","Zhao Y","Xin Z"],"additional_accession":[]},"is_claimable":false,"name":"Pan-Cancer Analysis of PTBP1 to Identify it as a Prognostic and Immunological Biomarker.","description":"<h4>Objectives</h4>Human cancer is considered to be an important cause of death worldwide. Polypyrimidine tract binding protein 1 (PTBP1) is emerging as a powerful pro-oncogenic factor in bladder and liver cancer; however, no pan-cancer analysis is presently available. Our study aimed to explore PTBP1 expression profiles, prognostic immunological value, and biological functions across various cancers.<h4>Methods</h4>We conducted a comprehensive analysis using multi-omics bioinformatics from public databases, including TIMER, GEPIA2, ProteinAtlas, Kaplan-Meier Plotter, PrognoScan, cBioPortal, STRING, ENCORI, TargetScan, and DAVID.<h4>Results</h4>We found that PTBP1 was overexpressed across multiple cancer types. qRT-PCR results demonstrated that the PTBP1 mRNA was significantly up-regulated","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan-Dec","modification":"2025-04-19T16:12:09.87Z","creation":"2025-04-19T16:12:09.87Z"},"accession":"S-EPMC11607764","cross_references":{"pubmed":["39612472"],"doi":["10.1177/10732748241302865"]}}