{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Jun H"],"pubmed_abstract":["<h4>Background</h4><i>Plasmodium falciparum</i> is the most lethal malaria parasite. Recent phase 1b vaccine trials using <i>P. falciparum</i> reticulocyte binding protein homolog 5 (PfRh5) demonstrated safety and promising efficacy in preventing merozoite invasion. PfRh5 has emerged as a strong vaccine candidate due to its essential role in merozoite invasion and limited sequence variation. For effective malaria vaccine development, especially in high-transmission settings, strain-transcending activity must be considered. Ongoing monitoring of antigenic variation and natural immune responses is important to estimate vaccine efficacy across geographically diverse populations.<h4>Methods</h4>Samples for this study were collected from four villages in each of the Kigoma and Geita regions, kn"],"journal":["Frontiers in immunology"],"pagination":["1495513"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11609159"],"repository":["biostudies-literature"],"pubmed_title":["Estimation of PfRh5-based vaccine efficacy in asymptomatic <i>Plasmodium falciparum</i> patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening."],"pmcid":["PMC11609159"],"pubmed_authors":["Hong M","Jun H","Na S","Park WS","Lee SJ","Todd J","Lee WJ","Lu F","Kidima W","Mazigo E","Han JH","Chun W","Kwon B","Muh F","Louis JM","Lee SU","Manjurano A","Heo J","Kim Y","Syahada JH","Kwon TH","Han ET","Fitriana F","Ahmed MA"],"additional_accession":[]},"is_claimable":false,"name":"Estimation of PfRh5-based vaccine efficacy in asymptomatic <i>Plasmodium falciparum</i> patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening.","description":"<h4>Background</h4><i>Plasmodium falciparum</i> is the most lethal malaria parasite. Recent phase 1b vaccine trials using <i>P. falciparum</i> reticulocyte binding protein homolog 5 (PfRh5) demonstrated safety and promising efficacy in preventing merozoite invasion. PfRh5 has emerged as a strong vaccine candidate due to its essential role in merozoite invasion and limited sequence variation. For effective malaria vaccine development, especially in high-transmission settings, strain-transcending activity must be considered. Ongoing monitoring of antigenic variation and natural immune responses is important to estimate vaccine efficacy across geographically diverse populations.<h4>Methods</h4>Samples for this study were collected from four villages in each of the Kigoma and Geita regions, kn","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T12:41:53.334Z","creation":"2025-04-04T01:20:59.146Z"},"accession":"S-EPMC11609159","cross_references":{"pubmed":["39624090"],"doi":["10.3389/fimmu.2024.1495513"]}}