biostudies-literatureUnknown15Jun H<h4>Background</h4><i>Plasmodium falciparum</i> is the most lethal malaria parasite. Recent phase 1b vaccine trials using <i>P. falciparum</i> reticulocyte binding protein homolog 5 (PfRh5) demonstrated safety and promising efficacy in preventing merozoite invasion. PfRh5 has emerged as a strong vaccine candidate due to its essential role in merozoite invasion and limited sequence variation. For effective malaria vaccine development, especially in high-transmission settings, strain-transcending activity must be considered. Ongoing monitoring of antigenic variation and natural immune responses is important to estimate vaccine efficacy across geographically diverse populations.<h4>Methods</h4>Samples for this study were collected from four villages in each of the Kigoma and Geita regions, knFrontiers in immunology1495513https://www.ebi.ac.uk/biostudies/studies/S-EPMC11609159biostudies-literatureEstimation of PfRh5-based vaccine efficacy in asymptomatic <i>Plasmodium falciparum</i> patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening.PMC11609159Hong MJun HNa SPark WSLee SJTodd JLee WJLu FKidima WMazigo EHan JHChun WKwon BMuh FLouis JMLee SUManjurano AHeo JKim YSyahada JHKwon THHan ETFitriana FAhmed MAfalseEstimation of PfRh5-based vaccine efficacy in asymptomatic <i>Plasmodium falciparum</i> patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening.<h4>Background</h4><i>Plasmodium falciparum</i> is the most lethal malaria parasite. Recent phase 1b vaccine trials using <i>P. falciparum</i> reticulocyte binding protein homolog 5 (PfRh5) demonstrated safety and promising efficacy in preventing merozoite invasion. PfRh5 has emerged as a strong vaccine candidate due to its essential role in merozoite invasion and limited sequence variation. For effective malaria vaccine development, especially in high-transmission settings, strain-transcending activity must be considered. Ongoing monitoring of antigenic variation and natural immune responses is important to estimate vaccine efficacy across geographically diverse populations.<h4>Methods</h4>Samples for this study were collected from four villages in each of the Kigoma and Geita regions, kn2024-01-01T00:00:00Z20242026-06-01T12:41:53.334Z2025-04-04T01:20:59.146ZS-EPMC116091593962409010.3389/fimmu.2024.1495513