{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29"],"submitter":["Hao Y"],"pubmed_abstract":["Traumatic brain injury (TBI) can lead to severe neurotrauma, leading to long-term cognitive decline and even death. Massive neuronal loss and excessive neuroinflammation are critical issues in the treatment of secondary TBI. To tackle these challenges, we developed a GelMA and CSMA hydrogel loaded with Erythropoietin (EPO) and Interleukin-4 (IL-4), named GC/I/E. By directly loading the hydrogel with EPO, rapid neuroprotection and angiogenesis were achieved. Meanwhile, by loading Mesoporous silica nanoparticles (MSNs) with IL-4 (MSN@IL-4), sustained inflammation modulation during inflammation was attained. <i>In vitro</i> experiments demonstrated that GC/I/E hydrogel were biocompatible and could provide neuroprotection for HT22 cells in H<sub>2</sub>O<sub>2</sub> environment, regulate RAW26"],"journal":["Materials today. Bio"],"pagination":["101335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11609671"],"repository":["biostudies-literature"],"pubmed_title":["Bioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury."],"pmcid":["PMC11609671"],"pubmed_authors":["Liu H","Zhou L","Feng L","Wang C","He X","Hao Y","Guo R","Cheng H","Yu X","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"Bioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury.","description":"Traumatic brain injury (TBI) can lead to severe neurotrauma, leading to long-term cognitive decline and even death. Massive neuronal loss and excessive neuroinflammation are critical issues in the treatment of secondary TBI. To tackle these challenges, we developed a GelMA and CSMA hydrogel loaded with Erythropoietin (EPO) and Interleukin-4 (IL-4), named GC/I/E. By directly loading the hydrogel with EPO, rapid neuroprotection and angiogenesis were achieved. Meanwhile, by loading Mesoporous silica nanoparticles (MSNs) with IL-4 (MSN@IL-4), sustained inflammation modulation during inflammation was attained. <i>In vitro</i> experiments demonstrated that GC/I/E hydrogel were biocompatible and could provide neuroprotection for HT22 cells in H<sub>2</sub>O<sub>2</sub> environment, regulate RAW26","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T00:21:50.065Z","creation":"2025-04-04T00:21:50.065Z"},"accession":"S-EPMC11609671","cross_references":{"pubmed":["39624047"],"doi":["10.1016/j.mtbio.2024.101335"]}}