biostudies-literatureLiu LBeijing Jingjian Pathology Development Foundationthe Natural Science Foundation of Shandong Provincethe National Natural Science Foundation of China1481https://www.ebi.ac.uk/biostudies/studies/S-EPMC11610093biostudies-literatureUnknown24(1)<h4>Background</h4>Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors with high mortality and poor prognosis. Its incidence rate is increasing gradually. Tumor necrosis factor receptor-associated factor interacting protein (TRAIP), as a factor related to several tumors, reveals that its gene expression is different between normal tissue and primary tumor of head and neck squamous cell carcinoma using bioinformatics analysis.<h4>Method</h4>In our study, TCGA database, immunohistochemistry, proliferation assay, colony formation, wound healing assay, Transwell, cell cycle analysis and tumor xenografts model were used to determine the expression and functions of TRAIP in TSCC.<h4>Result</h4>We found that TRAIP may promote the proliferation, migration and invasion BMC cancerTRAIP enhances progression of tongue squamous cell carcinoma through EMT and Wnt/β-catenin signaling by interacting with DDX39A.PMC11610093No.81672606JJlXA2022-008ZR2022MH206Song LZheng YWang PLiu LQi HWang CChen LXing XGuo CfalseTRAIP enhances progression of tongue squamous cell carcinoma through EMT and Wnt/β-catenin signaling by interacting with DDX39A.<h4>Background</h4>Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors with high mortality and poor prognosis. Its incidence rate is increasing gradually. Tumor necrosis factor receptor-associated factor interacting protein (TRAIP), as a factor related to several tumors, reveals that its gene expression is different between normal tissue and primary tumor of head and neck squamous cell carcinoma using bioinformatics analysis.<h4>Method</h4>In our study, TCGA database, immunohistochemistry, proliferation assay, colony formation, wound healing assay, Transwell, cell cycle analysis and tumor xenografts model were used to determine the expression and functions of TRAIP in TSCC.<h4>Result</h4>We found that TRAIP may promote the proliferation, migration and invasion 2024-01-01T00:00:00Z2024 Dec2025-04-04T02:20:07.377Z2025-04-04T02:20:07.377ZS-EPMC116100933962330610.1186/s12885-024-13130-8