{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ben-Crentsil NA"],"funding":["National Cancer Institute (NCI)","Moffitt Cancer Center (MCC)","Moffitt Cancer Center","National Cancer Institute","NCI NIH HHS"],"pagination":["2509-2531"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11611684"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(12)"],"pubmed_abstract":["<h4>Significance</h4>This work identifies MALAT1 as a requisite downstream effector of oncogenic feedforward inflammatory circuits necessary for the development of TET2-mutated CH and fulminant myeloid malignancy. We elucidate a novel mechanism by which MALAT1 \"shields\" p65 from dephosphorylation to potentiate this circuit and nominate MALAT1 inhibition as a future therapeutic strategy."],"journal":["Cancer discovery"],"pubmed_title":["RNA Shielding of p65 Is Required to Potentiate Oncogenic Inflammation in TET2-Mutated Clonal Hematopoiesis."],"pmcid":["PMC11611684"],"funding_grant_id":["1R21CA216757-01A1","P30-CA076292","P30 CA076292","R21 CA216757"],"pubmed_authors":["Beg AA","Ma L","Aldrich AL","Traina J","Mohammed Ismail W","Neupane S","Lasho TL","Ibrahim ML","Gaspar-Maia A","Binder M","Sallman DA","Padron E","Balasis ME","Wysota M","McLemore AF","Quintana A","Finke CM","Fernandez J","Ben-Crentsil NA","Droin N","Newman H","Ryder CB","McGraw KL","Solary E","Kruer T","Shastri A","Yun S","Ferrall-Fairbanks MC","Letson CT","Patnaik MM"],"additional_accession":[]},"is_claimable":false,"name":"RNA Shielding of p65 Is Required to Potentiate Oncogenic Inflammation in TET2-Mutated Clonal Hematopoiesis.","description":"<h4>Significance</h4>This work identifies MALAT1 as a requisite downstream effector of oncogenic feedforward inflammatory circuits necessary for the development of TET2-mutated CH and fulminant myeloid malignancy. We elucidate a novel mechanism by which MALAT1 \"shields\" p65 from dephosphorylation to potentiate this circuit and nominate MALAT1 inhibition as a future therapeutic strategy.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-02T08:54:10.475Z","creation":"2026-04-16T03:12:46.036Z"},"accession":"S-EPMC11611684","cross_references":{"pubmed":["39189614"],"doi":["10.1158/2159-8290.cd-24-0093","10.1158/2159-8290.CD-24-0093"]}}