{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Trapp S"],"funding":["Dutch Research Council (NWO)"],"pagination":["29988"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11612499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Separating medical radionuclides from their targets is one of the most critical steps in radiopharmaceutical production. Among many separation methods, solvent extraction has a lot of potential due to its simplicity, high selectivity, and high efficiency. Especially with the rise of polydimethylsiloxane (PDMS) microfluidic chips, this extraction process can take place in a simple and reproducible chip platform continuously and automatically. Furthermore, the microfluidic chips can be coated with metal-oxide nano-layers, increasing their resistance against the employed organic solvents. We fabricated such chips and demonstrated a parallel flow at a considerably large range of flow rates using the aqueous and organic solutions commonly used in medical radionuclide extraction. In our followin"],"journal":["Scientific reports"],"pubmed_title":["Solvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips."],"pmcid":["PMC11612499"],"funding_grant_id":["16913"],"pubmed_authors":["van Ommen JR","van Steijn V","de Kruijff RM","Hounat Y","Trapp S","Santoso A","Paulssen E"],"additional_accession":[]},"is_claimable":false,"name":"Solvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips.","description":"Separating medical radionuclides from their targets is one of the most critical steps in radiopharmaceutical production. Among many separation methods, solvent extraction has a lot of potential due to its simplicity, high selectivity, and high efficiency. Especially with the rise of polydimethylsiloxane (PDMS) microfluidic chips, this extraction process can take place in a simple and reproducible chip platform continuously and automatically. Furthermore, the microfluidic chips can be coated with metal-oxide nano-layers, increasing their resistance against the employed organic solvents. We fabricated such chips and demonstrated a parallel flow at a considerably large range of flow rates using the aqueous and organic solutions commonly used in medical radionuclide extraction. In our followin","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-27T04:46:11.726Z","creation":"2025-04-06T19:08:33.789Z"},"accession":"S-EPMC11612499","cross_references":{"pubmed":["39622906"],"doi":["10.1038/s41598-024-81177-5"]}}