biostudies-literatureTrapp SDutch Research Council (NWO)29988https://www.ebi.ac.uk/biostudies/studies/S-EPMC11612499biostudies-literatureUnknown14(1)Separating medical radionuclides from their targets is one of the most critical steps in radiopharmaceutical production. Among many separation methods, solvent extraction has a lot of potential due to its simplicity, high selectivity, and high efficiency. Especially with the rise of polydimethylsiloxane (PDMS) microfluidic chips, this extraction process can take place in a simple and reproducible chip platform continuously and automatically. Furthermore, the microfluidic chips can be coated with metal-oxide nano-layers, increasing their resistance against the employed organic solvents. We fabricated such chips and demonstrated a parallel flow at a considerably large range of flow rates using the aqueous and organic solutions commonly used in medical radionuclide extraction. In our followinScientific reportsSolvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips.PMC1161249916913van Ommen JRvan Steijn Vde Kruijff RMHounat YTrapp SSantoso APaulssen EfalseSolvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips.Separating medical radionuclides from their targets is one of the most critical steps in radiopharmaceutical production. Among many separation methods, solvent extraction has a lot of potential due to its simplicity, high selectivity, and high efficiency. Especially with the rise of polydimethylsiloxane (PDMS) microfluidic chips, this extraction process can take place in a simple and reproducible chip platform continuously and automatically. Furthermore, the microfluidic chips can be coated with metal-oxide nano-layers, increasing their resistance against the employed organic solvents. We fabricated such chips and demonstrated a parallel flow at a considerably large range of flow rates using the aqueous and organic solutions commonly used in medical radionuclide extraction. In our followin2024-01-01T00:00:00Z2024 Dec2025-04-27T04:46:11.726Z2025-04-06T19:08:33.789ZS-EPMC116124993962290610.1038/s41598-024-81177-5