{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96(12)"],"submitter":["Stich M"],"funding":["The study was funded by the Ministry of Science, Research and the Arts in Baden-Württemberg, Germany, within the framework of the special funding line for COVID-19 research, part of the measures to combat the SARS-CoV-2 pandemic in the field of medical research. Maximilian Stich was funded by the DZIF clinical leave stipend of the German Center for Infection Research."],"pubmed_abstract":["The pivotal role of the cell entry receptor ACE2 for SARS-CoV-2 infection is well-established. When ACE2 is shed from cell surface into plasma as soluble ACE2 (sACE2), it can effectively neutralize SARS-CoV-2. This longitudinal prospective cohort study analyzed sACE2 activity in 1192 participants, aged 4 months to 81 years, 3 and 12 months after SARS-CoV-2 household exposure. Following SARS-CoV-2 exposure, participants exhibited significantly elevated sACE2 activity, irrespective of confirmed infection, with the highest levels observed in exposed children. Longitudinal analysis revealed a decline in sACE2 levels over time, reaching levels comparable to age- and sex-matched pre-pandemic controls. An increase in sACE2 activity was also confirmed in vitro in Calu-3 (human lung) cells within h"],"journal":["Journal of medical virology"],"pagination":["e70098"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11612704"],"repository":["biostudies-literature"],"pubmed_title":["Elevated Soluble ACE2 Activity in Children and Adults After SARS-CoV-2 Exposure Irrespective of Laboratory-Confirmed Infection."],"pmcid":["PMC11612704"],"pubmed_authors":["Jacobsen EM","Lang P","Mohr K","Janda A","Renk H","Rabsteyn A","Bode SFN","Magalhaes VG","Krausslich HG","Okun JG","Bartenschlager R","Hoffmann GF","Burger F","Garbade SF","Jeltsch K","Binder M","Stich M","Elling R","Muller B","Haddad A","Tonshoff B"],"additional_accession":[]},"is_claimable":false,"name":"Elevated Soluble ACE2 Activity in Children and Adults After SARS-CoV-2 Exposure Irrespective of Laboratory-Confirmed Infection.","description":"The pivotal role of the cell entry receptor ACE2 for SARS-CoV-2 infection is well-established. When ACE2 is shed from cell surface into plasma as soluble ACE2 (sACE2), it can effectively neutralize SARS-CoV-2. This longitudinal prospective cohort study analyzed sACE2 activity in 1192 participants, aged 4 months to 81 years, 3 and 12 months after SARS-CoV-2 household exposure. Following SARS-CoV-2 exposure, participants exhibited significantly elevated sACE2 activity, irrespective of confirmed infection, with the highest levels observed in exposed children. Longitudinal analysis revealed a decline in sACE2 levels over time, reaching levels comparable to age- and sex-matched pre-pandemic controls. An increase in sACE2 activity was also confirmed in vitro in Calu-3 (human lung) cells within h","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:40:15.071Z","creation":"2025-04-04T01:40:15.071Z"},"accession":"S-EPMC11612704","cross_references":{"pubmed":["39624009"],"doi":["10.1002/jmv.70098"]}}