{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(5)"],"submitter":["Arroyo-Huidobro M"],"pubmed_abstract":["<h4>Objective</h4>This study aimed to describe the clinical presentation of COVID-19 in hospitalized patients aged 80 or above and to identify predictors for death and complications throughout the epidemic waves of the disease.<h4>Methods</h4>This was an observational, multicenter, ambispective study conducted between March 2020 and August 2021 using data collected in five centers from southern metropolitan area of Barcelona (COVID-MetroSud cohort). Patients were grouped based on the pandemic waves of inclusion in the registry. We conducted a descriptive analysis, followed by bivariate and multivariate analyses (binary logistic regression) to identify predictors of risk for death or complications.<h4>Results</h4>A total of 1192 patients (mean [SD] age 85.7 [4.22] years and 46.8% female) were included. The most frequently reported symptoms in all waves were fever (63.1%), cough (56.5%), dyspnea (48.2%), and asthenia (27.5%). Laboratory and radiological findings consistently showed abnormal bilateral chest X-ray results (72.5% of patients) and elevated inflammatory markers such as lactate dehydrogenase (mean [SD] 335 [188] U/L), C-reactive protein (CRP) (mean [SD] 110 [88.4] U/L), and ferritin (mean [SD] 842 [1561] U/L). Acute respiratory distress syndrome (43.7%), renal failure (19.2%), and delirium (17.5%) were the most frequent complications. The overall mortality rate was 41.4% and declined across the epidemic waves. Age, diabetes mellitus, heart failure, dyspnea, and higher baseline levels of creatinine were identified as risk factors for complications, while a higher Barthel index and presence of cough were found to be protective. Age, dyspnea, abnormal bilateral chest X-ray, CRP, and sodium were identified as risk factors for death.<h4>Conclusions</h4>This study demonstrates the clinical presentation of COVID-19 (fever, cough, dyspnea, and asthenia) and the different risk factors for mortality and complications in octogenarian hospitalized patients throughout the pandemic. These findings could be highly valuable for managing future virus pandemics."],"journal":["European geriatric medicine"],"pagination":["1477-1487"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11615005"],"repository":["biostudies-literature"],"pubmed_title":["Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study."],"pmcid":["PMC11615005"],"pubmed_authors":["Abelenda-Alonso G","Perez-Lopez C","Moreno E","Videla S","Hereu P","Carratala J","Sanmarti M","Bermudez IO","Gonzalez M","Besalu M","Cordomi CT","Molist G","Soto AL","Perez A","Arroyo-Huidobro M","MetroSud and Divine Study Group","Garmendia L","Diaz-Brito V","Gudiol C","Cobo E","Izquierdo E","Pallares N","Tebe C","Rombauts A","Perez-Alvarez N","Rodriguez-Molinero A","Faura A","Fernandez D","Piulachs X","Fontanet NP","Melis GG","Gomez G","Cruz P","Langohr K","Simonetti AF","Colom M","Aranda-Lobo J","Cortes J","Serrano L","Alvarez MC"],"additional_accession":[]},"is_claimable":false,"name":"Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study.","description":"<h4>Objective</h4>This study aimed to describe the clinical presentation of COVID-19 in hospitalized patients aged 80 or above and to identify predictors for death and complications throughout the epidemic waves of the disease.<h4>Methods</h4>This was an observational, multicenter, ambispective study conducted between March 2020 and August 2021 using data collected in five centers from southern metropolitan area of Barcelona (COVID-MetroSud cohort). Patients were grouped based on the pandemic waves of inclusion in the registry. We conducted a descriptive analysis, followed by bivariate and multivariate analyses (binary logistic regression) to identify predictors of risk for death or complications.<h4>Results</h4>A total of 1192 patients (mean [SD] age 85.7 [4.22] years and 46.8% female) were included. The most frequently reported symptoms in all waves were fever (63.1%), cough (56.5%), dyspnea (48.2%), and asthenia (27.5%). Laboratory and radiological findings consistently showed abnormal bilateral chest X-ray results (72.5% of patients) and elevated inflammatory markers such as lactate dehydrogenase (mean [SD] 335 [188] U/L), C-reactive protein (CRP) (mean [SD] 110 [88.4] U/L), and ferritin (mean [SD] 842 [1561] U/L). Acute respiratory distress syndrome (43.7%), renal failure (19.2%), and delirium (17.5%) were the most frequent complications. The overall mortality rate was 41.4% and declined across the epidemic waves. Age, diabetes mellitus, heart failure, dyspnea, and higher baseline levels of creatinine were identified as risk factors for complications, while a higher Barthel index and presence of cough were found to be protective. Age, dyspnea, abnormal bilateral chest X-ray, CRP, and sodium were identified as risk factors for death.<h4>Conclusions</h4>This study demonstrates the clinical presentation of COVID-19 (fever, cough, dyspnea, and asthenia) and the different risk factors for mortality and complications in octogenarian hospitalized patients throughout the pandemic. These findings could be highly valuable for managing future virus pandemics.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-05-09T19:03:53.137Z","creation":"2025-04-04T01:04:59.478Z"},"accession":"S-EPMC11615005","cross_references":{"pubmed":["39425809"],"doi":["10.1007/s41999-024-01063-1"]}}