biostudies-literatureUnknown15(1)Prasoon AThe chemistry of the on-water surface, characterized by enhanced reactivity, distinct selectivity, and confined reaction geometry, offers significant potential for chemical and materials syntheses. However, the utilization of on-water surface synthesis is currently limited by the requirement for a stable air-water interface, which restricts its broader synthetic applications. In this work, we present a approach that mimics on-water surface chemistry using micelles. This method involves the self-assembly of charged surfactant molecules beyond their critical micelle concentration (CMC), forming micellar structures that simulate the air-water interface. This creates an environment conducive to chemical reactions, featuring a hydrophobic core and surrounding water layer. Utilizing such mimickiNature communications10495https://www.ebi.ac.uk/biostudies/studies/S-EPMC11615243biostudies-literatureMimicking on-water surface synthesis through micellar interfaces.PMC11615243Yang HBrunner ENguyen NNAiti MAMuller AHerbawe AFeng XGhouse SPaasch SPrasoon ACuniberti GNaisa CfalseMimicking on-water surface synthesis through micellar interfaces.The chemistry of the on-water surface, characterized by enhanced reactivity, distinct selectivity, and confined reaction geometry, offers significant potential for chemical and materials syntheses. However, the utilization of on-water surface synthesis is currently limited by the requirement for a stable air-water interface, which restricts its broader synthetic applications. In this work, we present a approach that mimics on-water surface chemistry using micelles. This method involves the self-assembly of charged surfactant molecules beyond their critical micelle concentration (CMC), forming micellar structures that simulate the air-water interface. This creates an environment conducive to chemical reactions, featuring a hydrophobic core and surrounding water layer. Utilizing such mimicki2024-01-01T00:00:00Z2024 Dec2026-06-02T09:12:54.704Z2025-04-19T14:36:40.96ZS-EPMC116152433962721010.1038/s41467-024-54962-z