{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li MX"],"funding":["Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology)","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["10539"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11615374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Cancer cells secrete extracellular vesicles (EV) encapsulating bioactive cargoes to facilitate inter-organ communication in vivo and are emerging as critical mediators of tumor progression and metastasis, a condition which is often accompanied by a dysregulated cholesterol metabolism. Whether EVs are involved in the control of cholesterol homeostasis during tumor metastasis is still undefined and warrant further investigation. Here, we find that breast cancer-derived exosomal miR-9-5p induces the expression of HMGCR and CH25H, two enzymes involved in cholesterol synthesis and the conversion of 25-hydroxycholesterol from cholesterol by targeting INSIG1, INSIG2 and ATF3 genes in the liver. Notably, in vivo miR-9-5p antagomir treatment and genetic CH25H ablation prevents tumor metastasis in a"],"journal":["Nature communications"],"pubmed_title":["Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice."],"pmcid":["PMC11615374"],"funding_grant_id":["32270827","2021YFA0804803"],"pubmed_authors":["Zhang LM","Wu XT","Hu S","Hou WK","Yuan M","Xiao BW","Yan W","Li MX","Li X","Zhang XH","Fu D","Yu TX","Huang XJ","Jing WQ","Lee HJ","Li JJ","Lei HH"],"additional_accession":[]},"is_claimable":false,"name":"Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice.","description":"Cancer cells secrete extracellular vesicles (EV) encapsulating bioactive cargoes to facilitate inter-organ communication in vivo and are emerging as critical mediators of tumor progression and metastasis, a condition which is often accompanied by a dysregulated cholesterol metabolism. Whether EVs are involved in the control of cholesterol homeostasis during tumor metastasis is still undefined and warrant further investigation. Here, we find that breast cancer-derived exosomal miR-9-5p induces the expression of HMGCR and CH25H, two enzymes involved in cholesterol synthesis and the conversion of 25-hydroxycholesterol from cholesterol by targeting INSIG1, INSIG2 and ATF3 genes in the liver. Notably, in vivo miR-9-5p antagomir treatment and genetic CH25H ablation prevents tumor metastasis in a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:06:06.087Z","creation":"2025-04-04T01:06:06.087Z"},"accession":"S-EPMC11615374","cross_references":{"pubmed":["39627188"],"doi":["10.1038/s41467-024-54706-z"]}}