biostudies-literatureUnknown43(6)Lee HChristian Medical Research Center, Presbyterian Medical CenterBiomedical Research Institute, Jeonbuk National University Hospital<h4>Background</h4>Circulating microRNAs (miRNAs) are potential biomarkers for various kidney diseases. In this study, we aimed to identify a circulating miRNA signature for detecting acute kidney injury (AKI) in scrub typhus.<h4>Methods</h4>We prospectively enrolled 40 patients with scrub typhus (20 with AKI, AKI group; 20 without AKI, non-AKI group) and 20 healthy volunteers (the HV group). Thereafter, we performed microarray analysis to assess the serum miRNA profiles of all the participants. Then, to identify miRNAs predictive of scrub typhus-associated AKI, we compared miRNA profiles among these three groups.<h4>Results</h4>The proportions of miRNAs, small nucleolar RNAs, and small Cajal body-specific ribonucleoproteins were higher in patients with scrub typhus than in the HVs. FurtheKidney research and clinical practice797-806https://www.ebi.ac.uk/biostudies/studies/S-EPMC11615441biostudies-literatureCirculating microRNAs as markers for scrub typhus-associated acute kidney injury.PMC11615441Kim JMLee CSLee HOh JHLee KYCho AYSun IOfalseCirculating microRNAs as markers for scrub typhus-associated acute kidney injury.<h4>Background</h4>Circulating microRNAs (miRNAs) are potential biomarkers for various kidney diseases. In this study, we aimed to identify a circulating miRNA signature for detecting acute kidney injury (AKI) in scrub typhus.<h4>Methods</h4>We prospectively enrolled 40 patients with scrub typhus (20 with AKI, AKI group; 20 without AKI, non-AKI group) and 20 healthy volunteers (the HV group). Thereafter, we performed microarray analysis to assess the serum miRNA profiles of all the participants. Then, to identify miRNAs predictive of scrub typhus-associated AKI, we compared miRNA profiles among these three groups.<h4>Results</h4>The proportions of miRNAs, small nucleolar RNAs, and small Cajal body-specific ribonucleoproteins were higher in patients with scrub typhus than in the HVs. Furthe2024-01-01T00:00:00Z2024 Nov2026-06-03T00:35:48.254Z2025-04-19T14:40:22.413ZS-EPMC116154413962227410.23876/j.krcp.23.250