biostudies-literatureJo ENational Research Foundation of KoreaPusan National UniversityKorea Disease Control and Prevention Agency785-796https://www.ebi.ac.uk/biostudies/studies/S-EPMC11615453biostudies-literatureUnknown43(6)<h4>Background</h4>Transferrin saturation (TSAT) has been used as an indicator of iron deficiency. However, there is no consensus regarding its optimal range for patient with chronic kidney disease (CKD). We aimed to analyze the effect of TSAT on the prognosis of patients with non-dialysis CKD (NDCKD).<h4>Methods</h4>From 2011 to 2016, 2157 NDCKD patients with baseline TSAT measurements were followed for 10 years. Patients were divided into three groups based on baseline TSAT values: <25%, ≥25% and <45%, and ≥45%. All-cause mortality and 4-point major adverse cardiovascular events (MACE) were analyzed using multivariable Cox regression analysis. Other iron biomarkers and mortality were also analyzed.<h4>Results</h4>During a mean follow-up of 7.1 ± 2.9 years, 182 of a total of 2,157 patientKidney research and clinical practiceThe association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease.PMC116154532011E33003002011E3300300, 2012E3301100, 2013E3301600, 2013E 3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202,2019E320100, 2019E320101, 2019E320102, 2022-11-0072013E3301602RS-2023-002237642013E33016002016E33002002016E33002012016E3300202,2019E3201002023105100012019E3201012019E3201022012E33011002013E 33016012022-11-007Kim SWSeong EYYoo THKim HJJo EKim YKim JSong SHOh KHfalseThe association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease.<h4>Background</h4>Transferrin saturation (TSAT) has been used as an indicator of iron deficiency. However, there is no consensus regarding its optimal range for patient with chronic kidney disease (CKD). We aimed to analyze the effect of TSAT on the prognosis of patients with non-dialysis CKD (NDCKD).<h4>Methods</h4>From 2011 to 2016, 2157 NDCKD patients with baseline TSAT measurements were followed for 10 years. Patients were divided into three groups based on baseline TSAT values: <25%, ≥25% and <45%, and ≥45%. All-cause mortality and 4-point major adverse cardiovascular events (MACE) were analyzed using multivariable Cox regression analysis. Other iron biomarkers and mortality were also analyzed.<h4>Results</h4>During a mean follow-up of 7.1 ± 2.9 years, 182 of a total of 2,157 patient2024-01-01T00:00:00Z2024 Nov2025-04-04T01:15:08.444Z2025-04-04T01:15:08.444ZS-EPMC116154533893404210.23876/j.krcp.23.278