{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng L"],"funding":["Strategic Priority Research Program of the Chinese Academy of Sciences","National Key R&D Program of China","Program of Shanghai Academic/Technology Research Leader","Program of Shanghai Academic Research Leader","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["e2409457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11615762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(45)"],"pubmed_abstract":["The transition metal-catalyzed direct coupling reactions involving electron-rich Fischer carbene species are largely underdeveloped and remain a big challenge. Here, a direct coupling reaction of azoles and azine N-oxides is reported with Fischer copper carbene species bearing an α-siloxy group i, which can be in situ generated from acylsilanes catalytically under photoirradiation and redox-neutral conditions. This coupling reaction between electron-rich α-siloxy Fischer Cu-carbene species with hard carbanion nucleophiles may undergo a bimetallic relay process, which is confirmed by the kinetic analysis and in situ NMR analysis. This reaction features mild conditions and remarkable heterocycle compatibility. Notably, this protocol tolerates a series of azole or azine N-oxide derivatives, i"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Photoinduced Copper-Catalyzed Cross-Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay."],"pmcid":["PMC11615762"],"funding_grant_id":["22101291","2021YFA1500200","XDB0610000","22371293","22171277","23XD1424500"],"pubmed_authors":["Li YC","Wang P","Zheng L","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Photoinduced Copper-Catalyzed Cross-Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay.","description":"The transition metal-catalyzed direct coupling reactions involving electron-rich Fischer carbene species are largely underdeveloped and remain a big challenge. Here, a direct coupling reaction of azoles and azine N-oxides is reported with Fischer copper carbene species bearing an α-siloxy group i, which can be in situ generated from acylsilanes catalytically under photoirradiation and redox-neutral conditions. This coupling reaction between electron-rich α-siloxy Fischer Cu-carbene species with hard carbanion nucleophiles may undergo a bimetallic relay process, which is confirmed by the kinetic analysis and in situ NMR analysis. This reaction features mild conditions and remarkable heterocycle compatibility. Notably, this protocol tolerates a series of azole or azine N-oxide derivatives, i","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T00:46:40.71Z","creation":"2025-04-04T00:46:40.71Z"},"accession":"S-EPMC11615762","cross_references":{"pubmed":["39401407"],"doi":["10.1002/advs.202409457"]}}