{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28"],"submitter":["Han H"],"pubmed_abstract":["Chronic neuroinflammation is a principal cause of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The blood-brain barrier predominantly comprises endothelial cells, and their intercellular communication with pericytes and other cell types regulates neuroinflammation. Here, we develop a tubular, perfusable model of human cerebrovascular tissues to study neurodegenerative diseases using cerebrovascular-specific extracellular matrix bioink, derived from a complementary blend of brain- and blood-vessel-derived extracellular matrices. The endothelial cells and pericytes in the bioprinted constructs spontaneously self-assemble into a dual-layered structure, closely mimicking the anatomy of the blood-brain barrier. Moreover, the mature cerebrovascular tissue shows "],"journal":["Biomaterials research"],"pagination":["0115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11617618"],"repository":["biostudies-literature"],"pubmed_title":["Cerebrovascular-Specific Extracellular Matrix Bioink Promotes Blood-Brain Barrier Properties."],"pmcid":["PMC11617618"],"pubmed_authors":["Lee S","Paek SH","Han H","Yi HG","Gao G","Jang J"],"additional_accession":[]},"is_claimable":false,"name":"Cerebrovascular-Specific Extracellular Matrix Bioink Promotes Blood-Brain Barrier Properties.","description":"Chronic neuroinflammation is a principal cause of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The blood-brain barrier predominantly comprises endothelial cells, and their intercellular communication with pericytes and other cell types regulates neuroinflammation. Here, we develop a tubular, perfusable model of human cerebrovascular tissues to study neurodegenerative diseases using cerebrovascular-specific extracellular matrix bioink, derived from a complementary blend of brain- and blood-vessel-derived extracellular matrices. The endothelial cells and pericytes in the bioprinted constructs spontaneously self-assemble into a dual-layered structure, closely mimicking the anatomy of the blood-brain barrier. Moreover, the mature cerebrovascular tissue shows ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-18T12:53:56.569Z","creation":"2025-04-06T22:16:34.802Z"},"accession":"S-EPMC11617618","cross_references":{"pubmed":["39641002"],"doi":["10.34133/bmr.0115"]}}