biostudies-literatureUnknown28Han HChronic neuroinflammation is a principal cause of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The blood-brain barrier predominantly comprises endothelial cells, and their intercellular communication with pericytes and other cell types regulates neuroinflammation. Here, we develop a tubular, perfusable model of human cerebrovascular tissues to study neurodegenerative diseases using cerebrovascular-specific extracellular matrix bioink, derived from a complementary blend of brain- and blood-vessel-derived extracellular matrices. The endothelial cells and pericytes in the bioprinted constructs spontaneously self-assemble into a dual-layered structure, closely mimicking the anatomy of the blood-brain barrier. Moreover, the mature cerebrovascular tissue shows Biomaterials research0115https://www.ebi.ac.uk/biostudies/studies/S-EPMC11617618biostudies-literatureCerebrovascular-Specific Extracellular Matrix Bioink Promotes Blood-Brain Barrier Properties.PMC11617618Lee SPaek SHHan HYi HGGao GJang JfalseCerebrovascular-Specific Extracellular Matrix Bioink Promotes Blood-Brain Barrier Properties.Chronic neuroinflammation is a principal cause of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. The blood-brain barrier predominantly comprises endothelial cells, and their intercellular communication with pericytes and other cell types regulates neuroinflammation. Here, we develop a tubular, perfusable model of human cerebrovascular tissues to study neurodegenerative diseases using cerebrovascular-specific extracellular matrix bioink, derived from a complementary blend of brain- and blood-vessel-derived extracellular matrices. The endothelial cells and pericytes in the bioprinted constructs spontaneously self-assemble into a dual-layered structure, closely mimicking the anatomy of the blood-brain barrier. Moreover, the mature cerebrovascular tissue shows 2024-01-01T00:00:00Z20242025-04-18T12:53:56.569Z2025-04-06T22:16:34.802ZS-EPMC116176183964100210.34133/bmr.0115