{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kosse C"],"funding":["NINDS NIH HHS"],"pagination":["151-161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11618074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["636(8041)"],"pubmed_abstract":["The brain processes an array of stimuli, enabling the selection of appropriate behavioural responses, but the neural pathways linking interoceptive inputs to outputs for feeding are poorly understood<sup>1-3</sup>. Here we delineate a subcortical circuit in which brain-derived neurotrophic factor (BDNF)-expressing neurons in the ventromedial hypothalamus (VMH) directly connect interoceptive inputs to motor centres, controlling food consumption and jaw movements. VMH<sup>BDNF</sup> neuron inhibition increases food intake by gating motor sequences of feeding through projections to premotor areas of the jaw. When food is unavailable, VMH<sup>BDNF</sup> inhibition elicits consummatory behaviours directed at inanimate objects such as wooden blocks, and inhibition of perimesencephalic trigeminal"],"journal":["Nature"],"pubmed_title":["A subcortical feeding circuit linking an interoceptive node to jaw movement."],"pmcid":["PMC11618074"],"funding_grant_id":["K99 NS135647"],"pubmed_authors":["Kosse C","Ivanov J","Knight Z","Friedman J","Pellegrino K"],"additional_accession":[]},"is_claimable":false,"name":"A subcortical feeding circuit linking an interoceptive node to jaw movement.","description":"The brain processes an array of stimuli, enabling the selection of appropriate behavioural responses, but the neural pathways linking interoceptive inputs to outputs for feeding are poorly understood<sup>1-3</sup>. Here we delineate a subcortical circuit in which brain-derived neurotrophic factor (BDNF)-expressing neurons in the ventromedial hypothalamus (VMH) directly connect interoceptive inputs to motor centres, controlling food consumption and jaw movements. VMH<sup>BDNF</sup> neuron inhibition increases food intake by gating motor sequences of feeding through projections to premotor areas of the jaw. When food is unavailable, VMH<sup>BDNF</sup> inhibition elicits consummatory behaviours directed at inanimate objects such as wooden blocks, and inhibition of perimesencephalic trigeminal","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:15:32.206Z","creation":"2025-04-04T01:15:32.206Z"},"accession":"S-EPMC11618074","cross_references":{"pubmed":["39443799"],"doi":["10.1038/s41586-024-08098-1"]}}