biostudies-literatureYang LYNIGMS NIH HHS288https://www.ebi.ac.uk/biostudies/studies/S-EPMC11618342biostudies-literatureUnknown7(1)Lipid-protein interactions are crucial for virtually all biological processes in living cells. However, existing structural databases focusing on these interactions are limited to integral membrane proteins. A systematic understanding of diverse lipid-protein interactions also encompassing lipid-anchored, peripheral membrane and soluble lipid binding proteins remains to be elucidated. To address this gap and facilitate the research of universal lipid-protein assemblies, we developed BioDolphin - a curated database with over 127,000 lipid-protein interactions. BioDolphin provides comprehensive annotations, including protein functions, protein families, lipid classifications, lipid-protein binding affinities, membrane association type, and atomic structures. Accessible via a publicly availabCommunications chemistryBioDolphin as a comprehensive database of lipid-protein binding interactions.PMC11618342R35 GM150890Yang LYPing KLuo YMcShan ACfalseBioDolphin as a comprehensive database of lipid-protein binding interactions.Lipid-protein interactions are crucial for virtually all biological processes in living cells. However, existing structural databases focusing on these interactions are limited to integral membrane proteins. A systematic understanding of diverse lipid-protein interactions also encompassing lipid-anchored, peripheral membrane and soluble lipid binding proteins remains to be elucidated. To address this gap and facilitate the research of universal lipid-protein assemblies, we developed BioDolphin - a curated database with over 127,000 lipid-protein interactions. BioDolphin provides comprehensive annotations, including protein functions, protein families, lipid classifications, lipid-protein binding affinities, membrane association type, and atomic structures. Accessible via a publicly availab2024-01-01T00:00:00Z2024 Dec2026-06-01T20:40:06.423Z2025-04-06T17:31:13.041ZS-EPMC116183423963302110.1038/s42004-024-01384-z