{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Naylor-Adamson L"],"funding":["British Heart Foundation","Medical Research Council"],"pagination":["1052-1063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11619005"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["Quantum dots (QDs) are semiconducting inorganic nanocrystals, that have garnered interest in biological and medical spheres due, to their potential benefits in biomedical imaging and drug-delivery systems. Indium phosphide QDs shelled with zinc sulphide (InP/ZnS) are viewed as more biocompatible than previous heavy metal based QDs. However, little is known about how InP/ZnS QDs affect a key blood cell, the platelet. Understanding how platelets interact with QDs is critical as unwanted activation can lead to pathological thrombus formation. Herein, we demonstrate PEGylation of InP/ZnS QDs coated with lipoic acid (QD-LA) or coated with penicillamine (QD-Pen) surface ligands induced markedly less platelet aggregation, platelet-QD interactions, integrin activation, alpha granule secretion and "],"journal":["Journal of materials chemistry. B"],"pubmed_title":["PEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation."],"pmcid":["PMC11619005"],"funding_grant_id":["MR/T002573/1","FS/PhD/22/29265"],"pubmed_authors":["Hondow N","Leonard SVL","Booth Z","Price TW","Stasiuk GJ","Chamberlain T","Naseem K","Schneider JE","Tung LD","Aslam Z","Allsup D","Harvell-Smith S","Calaminus SDJ","Thi Kim Thanh N","Naylor-Adamson L","Bouillard JG","Gallo J"],"additional_accession":[]},"is_claimable":false,"name":"PEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation.","description":"Quantum dots (QDs) are semiconducting inorganic nanocrystals, that have garnered interest in biological and medical spheres due, to their potential benefits in biomedical imaging and drug-delivery systems. Indium phosphide QDs shelled with zinc sulphide (InP/ZnS) are viewed as more biocompatible than previous heavy metal based QDs. However, little is known about how InP/ZnS QDs affect a key blood cell, the platelet. Understanding how platelets interact with QDs is critical as unwanted activation can lead to pathological thrombus formation. Herein, we demonstrate PEGylation of InP/ZnS QDs coated with lipoic acid (QD-LA) or coated with penicillamine (QD-Pen) surface ligands induced markedly less platelet aggregation, platelet-QD interactions, integrin activation, alpha granule secretion and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T02:35:16.26Z","creation":"2025-04-04T02:35:16.26Z"},"accession":"S-EPMC11619005","cross_references":{"pubmed":["39635869"],"doi":["10.1039/d4tb01334d"]}}