biostudies-literatureNaylor-Adamson LBritish Heart FoundationMedical Research Council1052-1063https://www.ebi.ac.uk/biostudies/studies/S-EPMC11619005biostudies-literatureUnknown13(3)Quantum dots (QDs) are semiconducting inorganic nanocrystals, that have garnered interest in biological and medical spheres due, to their potential benefits in biomedical imaging and drug-delivery systems. Indium phosphide QDs shelled with zinc sulphide (InP/ZnS) are viewed as more biocompatible than previous heavy metal based QDs. However, little is known about how InP/ZnS QDs affect a key blood cell, the platelet. Understanding how platelets interact with QDs is critical as unwanted activation can lead to pathological thrombus formation. Herein, we demonstrate PEGylation of InP/ZnS QDs coated with lipoic acid (QD-LA) or coated with penicillamine (QD-Pen) surface ligands induced markedly less platelet aggregation, platelet-QD interactions, integrin activation, alpha granule secretion and Journal of materials chemistry. BPEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation.PMC11619005MR/T002573/1FS/PhD/22/29265Hondow NLeonard SVLBooth ZPrice TWStasiuk GJChamberlain TNaseem KSchneider JETung LDAslam ZAllsup DHarvell-Smith SCalaminus SDJThi Kim Thanh NNaylor-Adamson LBouillard JGGallo JfalsePEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation.Quantum dots (QDs) are semiconducting inorganic nanocrystals, that have garnered interest in biological and medical spheres due, to their potential benefits in biomedical imaging and drug-delivery systems. Indium phosphide QDs shelled with zinc sulphide (InP/ZnS) are viewed as more biocompatible than previous heavy metal based QDs. However, little is known about how InP/ZnS QDs affect a key blood cell, the platelet. Understanding how platelets interact with QDs is critical as unwanted activation can lead to pathological thrombus formation. Herein, we demonstrate PEGylation of InP/ZnS QDs coated with lipoic acid (QD-LA) or coated with penicillamine (QD-Pen) surface ligands induced markedly less platelet aggregation, platelet-QD interactions, integrin activation, alpha granule secretion and 2025-01-01T00:00:00Z2025 Jan2025-04-04T02:35:16.26Z2025-04-04T02:35:16.26ZS-EPMC116190053963586910.1039/d4tb01334d