biostudies-literatureUnknown120(6)Curhan SGNational Institute on Deafness and Other Communication DisordersNational Institutes of Health<h4>Background</h4>Persistent tinnitus is common, disabling, and difficult to treat. Diet has been implicated in tinnitus etiology, but studies are inconsistent, and longitudinal data are scarce. Seafood intake is associated with a lower risk of hearing loss, but the longitudinal association with tinnitus is unknown.<h4>Objectives</h4>We examined the independent associations of seafood intake, fish oil supplement use, and risk of developing persistent tinnitus.<h4>Methods</h4>This prospective cohort study followed 73,482 females in the Nurses' Health Study II from 1991 to 2021. Diet was assessed using a validated food frequency questionnaire every 4 y. Multivariable-adjusted Cox proportional hazards regression was used to evaluate independent associations between total seafood intake, specThe American journal of clinical nutrition1409-1418https://www.ebi.ac.uk/biostudies/studies/S-EPMC11619791biostudies-literatureLongitudinal study of seafood and fish oil supplement intake and risk of persistent tinnitus.PMC11619791Zeleznik OACurhan SGCurhan GCfalseLongitudinal study of seafood and fish oil supplement intake and risk of persistent tinnitus.<h4>Background</h4>Persistent tinnitus is common, disabling, and difficult to treat. Diet has been implicated in tinnitus etiology, but studies are inconsistent, and longitudinal data are scarce. Seafood intake is associated with a lower risk of hearing loss, but the longitudinal association with tinnitus is unknown.<h4>Objectives</h4>We examined the independent associations of seafood intake, fish oil supplement use, and risk of developing persistent tinnitus.<h4>Methods</h4>This prospective cohort study followed 73,482 females in the Nurses' Health Study II from 1991 to 2021. Diet was assessed using a validated food frequency questionnaire every 4 y. Multivariable-adjusted Cox proportional hazards regression was used to evaluate independent associations between total seafood intake, spec2024-01-01T00:00:00Z2024 Dec2026-06-03T21:32:42.27Z2026-05-01T03:11:15.666ZS-EPMC116197913934929310.1016/j.ajcnut.2024.09.028