{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chahine ZM"],"funding":["NIAID NIH HHS","University of California, Riverside","NIH HHS"],"pagination":["RP92499"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11620747"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["The environmental challenges the human malaria parasite, <i>Plasmodium falciparum</i>, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regulation. Microrchidia (MORC) proteins have been implicated in DNA compaction and gene silencing across plant and animal kingdoms. Accumulating evidence has shed light on the role MORC protein plays as a transcriptional switch in apicomplexan parasites. In this study, using the CRISPR/Cas9 genome editing tool along with complementary molecular and genomics approaches, we demonstrate that <i>Pf</i>MORC not only modulates chromatin structure and heterochromatin formation throughout the parasite erythrocytic cycle, but is also essential to the parasite su"],"journal":["eLife"],"pubmed_title":["&lt;i&gt;Pf&lt;/i&gt;MORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, &lt;i&gt;Plasmodium falciparum&lt;/i&gt;."],"pmcid":["PMC11620747"],"funding_grant_id":["R21 AI142506","NIFA-Hatch-225935","S10 OD026929","R01 AI136511"],"pubmed_authors":["Bhanvadia S","Abel S","Saraf A","Chahine ZM","Hollin T","Lenz T","Prudhomme J","Banks C","Florens LA","Gupta M","Le Roch KG"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Pf&lt;/i&gt;MORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, &lt;i&gt;Plasmodium falciparum&lt;/i&gt;.","description":"The environmental challenges the human malaria parasite, <i>Plasmodium falciparum</i>, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regulation. Microrchidia (MORC) proteins have been implicated in DNA compaction and gene silencing across plant and animal kingdoms. Accumulating evidence has shed light on the role MORC protein plays as a transcriptional switch in apicomplexan parasites. In this study, using the CRISPR/Cas9 genome editing tool along with complementary molecular and genomics approaches, we demonstrate that <i>Pf</i>MORC not only modulates chromatin structure and heterochromatin formation throughout the parasite erythrocytic cycle, but is also essential to the parasite su","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-03T23:52:03.368Z","creation":"2025-04-03T23:52:03.368Z"},"accession":"S-EPMC11620747","cross_references":{"pubmed":["39636094"],"doi":["10.7554/eLife.92499"]}}