{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Surendrakumar R"],"funding":["Nehru Memorial College, Puthanampatti, Trichy, Tamil Nadu, India","King Saud University"],"pagination":["2371-2382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11622802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(22)"],"pubmed_abstract":["<b>Aim:</b> The amination and cyclization method developed a new strategy for designing and assembling new 1,4-dihydropyridine derivatives of compounds 3a-g and 4a-g.<b>Methods & materials:</b> Newly prepared pyridine compounds are more economical, and reduce the reaction time. FT-IR, <sup>1</sup>H-NMR, 13C-NMR, mass spectroscopy and elemental analyses elucidated the synthesized derivatives. All the derivatives are subjected to <i>in vitro</i> assay against MCF-7 (breast) and anti-bacterial activity.<b>Results:</b> In the anti-bacterial activity compound <b>3c</b> is moderately active against <i>Escherichia coli</i> (6.0 g/ml), and <b>4c</b> is extremely active against Lactiplantibacillus <i>plantarum</i> (10.0 g/ml) compared with standard Erythromycin. In cytotoxic activity, the compound "],"journal":["Future medicinal chemistry"],"pubmed_title":["Synthesis of new 1,4-dihydropyridine derivative, anti-cancer, bacterial activity, molecular docking and adsorption, distribution, metabolism and excretion analysis."],"pmcid":["PMC11622802"],"funding_grant_id":["RSPD2024R845","SR/FST/COLLEGE-372/2018"],"pubmed_authors":["Idhayadhulla A","Elangovan N","Surendrakumar R","Govindasamy T","Aldosari E","Islam MS"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of new 1,4-dihydropyridine derivative, anti-cancer, bacterial activity, molecular docking and adsorption, distribution, metabolism and excretion analysis.","description":"<b>Aim:</b> The amination and cyclization method developed a new strategy for designing and assembling new 1,4-dihydropyridine derivatives of compounds 3a-g and 4a-g.<b>Methods & materials:</b> Newly prepared pyridine compounds are more economical, and reduce the reaction time. FT-IR, <sup>1</sup>H-NMR, 13C-NMR, mass spectroscopy and elemental analyses elucidated the synthesized derivatives. All the derivatives are subjected to <i>in vitro</i> assay against MCF-7 (breast) and anti-bacterial activity.<b>Results:</b> In the anti-bacterial activity compound <b>3c</b> is moderately active against <i>Escherichia coli</i> (6.0 g/ml), and <b>4c</b> is extremely active against Lactiplantibacillus <i>plantarum</i> (10.0 g/ml) compared with standard Erythromycin. In cytotoxic activity, the compound ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-04T16:33:17.96Z","creation":"2026-05-13T14:24:39.339Z"},"accession":"S-EPMC11622802","cross_references":{"pubmed":["39440485"],"doi":["10.1080/17568919.2024.2403960"]}}