biostudies-literatureSurendrakumar RNehru Memorial College, Puthanampatti, Trichy, Tamil Nadu, IndiaKing Saud University2371-2382https://www.ebi.ac.uk/biostudies/studies/S-EPMC11622802biostudies-literatureUnknown16(22)<b>Aim:</b> The amination and cyclization method developed a new strategy for designing and assembling new 1,4-dihydropyridine derivatives of compounds 3a-g and 4a-g.<b>Methods & materials:</b> Newly prepared pyridine compounds are more economical, and reduce the reaction time. FT-IR, ¹H-NMR, 13C-NMR, mass spectroscopy and elemental analyses elucidated the synthesized derivatives. All the derivatives are subjected to <i>in vitro</i> assay against MCF-7 (breast) and anti-bacterial activity.<b>Results:</b> In the anti-bacterial activity compound <b>3c</b> is moderately active against <i>Escherichia coli</i> (6.0 g/ml), and <b>4c</b> is extremely active against Lactiplantibacillus <i>plantarum</i> (10.0 g/ml) compared with standard Erythromycin. In cytotoxic activity, the compound Future medicinal chemistrySynthesis of new 1,4-dihydropyridine derivative, anti-cancer, bacterial activity, molecular docking and adsorption, distribution, metabolism and excretion analysis.PMC11622802RSPD2024R845SR/FST/COLLEGE-372/2018Idhayadhulla AElangovan NSurendrakumar RGovindasamy TAldosari EIslam MSfalseSynthesis of new 1,4-dihydropyridine derivative, anti-cancer, bacterial activity, molecular docking and adsorption, distribution, metabolism and excretion analysis.<b>Aim:</b> The amination and cyclization method developed a new strategy for designing and assembling new 1,4-dihydropyridine derivatives of compounds 3a-g and 4a-g.<b>Methods & materials:</b> Newly prepared pyridine compounds are more economical, and reduce the reaction time. FT-IR, ¹H-NMR, 13C-NMR, mass spectroscopy and elemental analyses elucidated the synthesized derivatives. All the derivatives are subjected to <i>in vitro</i> assay against MCF-7 (breast) and anti-bacterial activity.<b>Results:</b> In the anti-bacterial activity compound <b>3c</b> is moderately active against <i>Escherichia coli</i> (6.0 g/ml), and <b>4c</b> is extremely active against Lactiplantibacillus <i>plantarum</i> (10.0 g/ml) compared with standard Erythromycin. In cytotoxic activity, the compound 2024-01-01T00:00:00Z20242026-06-04T16:33:17.96Z2026-05-13T14:24:39.339ZS-EPMC116228023944048510.1080/17568919.2024.2403960