{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baldwin JG"],"funding":["Joachim Herz Foundation","German Research Foundation","Ministry of Health","Else Kroner-Fresenius Foundation","National Institutes of Health","Cancer Research Institute","European Innovation Council","European Research Council","Federal Ministry of Education and Research Bonn Office","Fondazione AIRC per la ricerca sul cancro ETS","National Cancer Institute","NCI NIH HHS","Australian American Educational Foundation"],"pagination":["6614-6630.e21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11623344"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["187(23)"],"pubmed_abstract":["Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming these limitations. We found that bone marrow stromal cells establish nanotubular connections with T cells and leverage these intercellular highways to transplant stromal cell mitochondria into CD8<sup>+</sup> T cells. Optimal mitochondrial transfer required Talin 2 on both donor and recipient cells. CD8<sup>+</sup> T cells with donated mitochondria displayed enhanced mitochondrial respiration and spare respiratory capacity. When transferred into tumor-bearing hosts, these supercharged T cells expanded more robustly, infiltrated the tumor more efficiently, and exhib"],"journal":["Cell"],"pubmed_title":["Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy."],"pmcid":["PMC11623344"],"funding_grant_id":["957502","R01 CA135242","R01 CA293908","725038","R01 CA276525"],"pubmed_authors":["Inverso D","Raimondi A","Higgs BW","Rana N","Gebhard C","Telford WG","Baldwin JG","Iannacone M","Mastrogiovanni F","Rehli M","Sengupta S","Gautam S","Slavkovic-Lukic D","Strieder N","Barden M","Martin-Santos A","Frischholz S","Gattinoni L","Schober K","Fioravanti J","Kapoor V","Kontarakis Z","Saha T","Schelker RC","Corn JE","Beckhove P","Xydia M","Brohawn P","Heuser-Loy C","Hernandez-Lopez I"],"additional_accession":[]},"is_claimable":false,"name":"Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy.","description":"Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming these limitations. We found that bone marrow stromal cells establish nanotubular connections with T cells and leverage these intercellular highways to transplant stromal cell mitochondria into CD8<sup>+</sup> T cells. Optimal mitochondrial transfer required Talin 2 on both donor and recipient cells. CD8<sup>+</sup> T cells with donated mitochondria displayed enhanced mitochondrial respiration and spare respiratory capacity. When transferred into tumor-bearing hosts, these supercharged T cells expanded more robustly, infiltrated the tumor more efficiently, and exhib","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-06T16:03:35.029Z","creation":"2026-06-02T03:11:38.656Z"},"accession":"S-EPMC11623344","cross_references":{"pubmed":["39276774"],"doi":["10.1016/j.cell.2024.08.029"]}}