{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee Y"],"funding":["NINDS NIH HHS","National Institutes of Health","W M Keck Foundation"],"pagination":["411-421"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11624092"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["123"],"pubmed_abstract":["Interleukin-1β (IL1), a pleiotropic cytokine, is involved in sleep regulation, tumor ontogeny, and immune responses. IL1 receptor adaptor proteins, including the IL1 receptor accessory protein (AcP), and its neuron-specific isoform, AcPb, are required for IL1 signaling. The AcPb isoform is resultant from alternate splicing of the AcP transcript. Our previous studies using AcPb null (AcPb<sup>-/-</sup>) mice characterized its participation in sleep regulation and emergent neuronal/glial network properties. Here, we investigated the impact of acute sleep disruption (SD) on brain cancer-related pathways in wild-type (WT) and AcPb<sup>-/-</sup> mice, employing RNA sequencing methods. In WT mice, SD increased AcPb mRNA levels, but not AcP mRNA, confirming prior similar work in rats. Transcripto"],"journal":["Brain, behavior, and immunity"],"pubmed_title":["Sleep loss-induced oncogenic pathways are mediated via the neuron-specific interleukin-1 receptor accessory protein (AcPb)."],"pmcid":["PMC11624092"],"funding_grant_id":["R01 NS025378"],"pubmed_authors":["Liu Y","Schwartzmann CM","Krueger JM","English EL","Lee Y"],"additional_accession":[]},"is_claimable":false,"name":"Sleep loss-induced oncogenic pathways are mediated via the neuron-specific interleukin-1 receptor accessory protein (AcPb).","description":"Interleukin-1β (IL1), a pleiotropic cytokine, is involved in sleep regulation, tumor ontogeny, and immune responses. IL1 receptor adaptor proteins, including the IL1 receptor accessory protein (AcP), and its neuron-specific isoform, AcPb, are required for IL1 signaling. The AcPb isoform is resultant from alternate splicing of the AcP transcript. Our previous studies using AcPb null (AcPb<sup>-/-</sup>) mice characterized its participation in sleep regulation and emergent neuronal/glial network properties. Here, we investigated the impact of acute sleep disruption (SD) on brain cancer-related pathways in wild-type (WT) and AcPb<sup>-/-</sup> mice, employing RNA sequencing methods. In WT mice, SD increased AcPb mRNA levels, but not AcP mRNA, confirming prior similar work in rats. Transcripto","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-07-15T13:51:51.334Z","creation":"2026-07-05T03:11:30.004Z"},"accession":"S-EPMC11624092","cross_references":{"pubmed":["39343106"],"doi":["10.1016/j.bbi.2024.09.029"]}}