biostudies-literatureUnknown14Goertzen AEarly detection of cancer typically facilitates improved patient outcomes; however, many cancers are not easily diagnosed at an early stage. One potential route for developing new, non-invasive methods of cancer detection is by testing for cancer-related volatile organic compounds (VOCs) biomarkers in patients' urine. In this review, 44 studies covering the use and/or identification of cancer-related VOCs were examined, including studies which examined multiple types of cancer simultaneously, as well as diverse study designs. Among these studies the most studied cancers included prostate cancer (29% of papers), lung cancer (22%), breast cancer (20%), and bladder cancer (18%), with a smaller number of studies focused on colorectal cancer, cervical cancer, skin, liver cancer and others. ImpoFrontiers in oncology1448760https://www.ebi.ac.uk/biostudies/studies/S-EPMC11626232biostudies-literaturePotential urinary volatile organic compounds as screening markers in cancer - a review.PMC11626232Kidane BGoertzen AAhmed NAliani MfalsePotential urinary volatile organic compounds as screening markers in cancer - a review.Early detection of cancer typically facilitates improved patient outcomes; however, many cancers are not easily diagnosed at an early stage. One potential route for developing new, non-invasive methods of cancer detection is by testing for cancer-related volatile organic compounds (VOCs) biomarkers in patients' urine. In this review, 44 studies covering the use and/or identification of cancer-related VOCs were examined, including studies which examined multiple types of cancer simultaneously, as well as diverse study designs. Among these studies the most studied cancers included prostate cancer (29% of papers), lung cancer (22%), breast cancer (20%), and bladder cancer (18%), with a smaller number of studies focused on colorectal cancer, cervical cancer, skin, liver cancer and others. Impo2024-01-01T00:00:00Z20242026-04-08T15:23:09.914Z2025-04-06T17:31:17.903ZS-EPMC116262323965506910.3389/fonc.2024.1448760