{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paulus A"],"funding":["Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)","Bundesministerium für Bildung und Forschung"],"pagination":["10657"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11628618"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Organelle-specific protein translocation systems are essential for organelle biogenesis and maintenance in eukaryotes but thought to be absent from prokaryotic organelles. Here, we demonstrate that MamF-like proteins are crucial for the formation and functionality of bacterial magnetosome organelles. Deletion of mamF-like genes in the Alphaproteobacterium Magnetospirillum gryphiswaldense results in severe defects in organelle positioning, biomineralization, and magnetic navigation. These phenotypic defects result from the disrupted targeting of a subset of magnetosomal proteins that contain C-terminal glycine-rich integral membrane domains. Phylogenetic analyses reveal an ancient evolutionary link between MamF-like proteins and plastidial Tic20. Our findings redefine the molecular roles of"],"journal":["Nature communications"],"pubmed_title":["MamF-like proteins are distant Tic20 homologs involved in organelle assembly in bacteria."],"pmcid":["PMC11628618"],"funding_grant_id":["MagBioFab"],"pubmed_authors":["Becher D","Hofmann H","Schraut A","Ahrens F","Uebe R","Paulus A","Sura T","Schiller T"],"additional_accession":[]},"is_claimable":false,"name":"MamF-like proteins are distant Tic20 homologs involved in organelle assembly in bacteria.","description":"Organelle-specific protein translocation systems are essential for organelle biogenesis and maintenance in eukaryotes but thought to be absent from prokaryotic organelles. Here, we demonstrate that MamF-like proteins are crucial for the formation and functionality of bacterial magnetosome organelles. Deletion of mamF-like genes in the Alphaproteobacterium Magnetospirillum gryphiswaldense results in severe defects in organelle positioning, biomineralization, and magnetic navigation. These phenotypic defects result from the disrupted targeting of a subset of magnetosomal proteins that contain C-terminal glycine-rich integral membrane domains. Phylogenetic analyses reveal an ancient evolutionary link between MamF-like proteins and plastidial Tic20. Our findings redefine the molecular roles of","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-05-04T06:53:20.655Z","creation":"2025-04-06T17:31:24.123Z"},"accession":"S-EPMC11628618","cross_references":{"pubmed":["39653729"],"doi":["10.1038/s41467-024-55121-0"]}}