{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martin M"],"funding":["European Research Council"],"pagination":["17286-17292"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11629295"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(23)"],"pubmed_abstract":["Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp<sup>3</sup>-Csp<sup>2</sup> bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules."],"journal":["ACS catalysis"],"pubmed_title":["Csp&lt;sup&gt;3&lt;/sup&gt;-Csp&lt;sup&gt;2&lt;/sup&gt; Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process."],"pmcid":["PMC11629295"],"funding_grant_id":["101002715"],"pubmed_authors":["Romero RM","Portolani C","Martin M","Tortosa M"],"additional_accession":[]},"is_claimable":false,"name":"Csp&lt;sup&gt;3&lt;/sup&gt;-Csp&lt;sup&gt;2&lt;/sup&gt; Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process.","description":"Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp<sup>3</sup>-Csp<sup>2</sup> bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-26T23:24:26.424Z","creation":"2025-04-06T17:31:38.346Z"},"accession":"S-EPMC11629295","cross_references":{"pubmed":["39664777"],"doi":["10.1021/acscatal.4c06269"]}}