biostudies-literatureMartin MEuropean Research Council17286-17292https://www.ebi.ac.uk/biostudies/studies/S-EPMC11629295biostudies-literatureUnknown14(23)Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp³-Csp² bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules.ACS catalysisCsp<sup>3</sup>-Csp<sup>2</sup> Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process.PMC11629295101002715Romero RMPortolani CMartin MTortosa MfalseCsp<sup>3</sup>-Csp<sup>2</sup> Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process.Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp³-Csp² bond formation. This protocol allows for the preparation of functionalized heteroarenes from readily available isonitriles through a decyanation process. The reaction is general for primary, secondary, and tertiary substrates, including amino acid derivatives and druglike molecules.2024-01-01T00:00:00Z2024 Dec2025-04-26T23:24:26.424Z2025-04-06T17:31:38.346ZS-EPMC116292953966477710.1021/acscatal.4c06269