{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feenstra L"],"funding":["Viertel Charitable Foundation","John Perrett Bequest","Dutch Kidney Foundation","De Cock-Hadders Scientific Research Foundation","Graduated School of Medical Sciences of the University of Groningen","Health Holland","Astellas Pharma Europe"],"pagination":["1953-1966"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11629976"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(15)"],"pubmed_abstract":["Aims
Calciprotein particles (CPPs) are circulating calcium and phosphate nanoparticles associated with the development of vascular calcification (VC) in chronic kidney disease (CKD). Although recent studies have been focusing on associations of CPPs with the presence of VC in CKD, insights in the underlying processes and mechanisms by which CPPs might aggravate VC and vascular dysfunction in vivo are currently lacking. Here, we assessed the overall burden of abdominal VC in healthy kidney donors and CKD patients and subsequently performed transcriptome profiling in the vascular tissue obtained from these subjects, linking outcome to CPP counts and calcification propensity.Methods and results
Calcification scores were quantified in renal arteries, iliac arteries, and abdomin"],"journal":["Cardiovascular research"],"pubmed_title":["Calciprotein particle counts associate with vascular remodelling in chronic kidney disease."],"pmcid":["PMC11629976"],"funding_grant_id":["16TKI02","LSHM17034-HSGF"],"pubmed_authors":["Visser LM","Daan Touw J","Blokzijl H","Greuter MJW","Mulder DJ","Frank Bodewes AJA","Erik Verschuuren AM","Sanders JF","Slart RJHJA","van Pelt LJ","Cas Swarte J","Erasmus ME","van Leer-Buter C","Niesters HGM","de Meijer VE","Reijrink M","Damman K","Weersma RK","Pasch A","Hak E","van Londen M","Krenning G","Porte RJ","TransplantLines Investigators","Doorenbos CSE","Smith ER","Lexmond WS","Bouke Hepkema G","Neto AWG","de Boer MT","Adelita Ranchor V","Vos MJ","Pol RA","Te Velde-Keyzer CA","van den Heuvel MC","Hillebrands JL","Tji Gan C","Mastik MF","Douwes RM","Slart RHJA","Siebelink MJ","Lodewijk ME","Feenstra L","Klont F","Diepstra A","Henri Leuvenink GD","Dijkstra G","Bulthuis M","Gertrude Nieuwenhuis-Moeke J"],"additional_accession":[]},"is_claimable":false,"name":"Calciprotein particle counts associate with vascular remodelling in chronic kidney disease.","description":"Aims
Calciprotein particles (CPPs) are circulating calcium and phosphate nanoparticles associated with the development of vascular calcification (VC) in chronic kidney disease (CKD). Although recent studies have been focusing on associations of CPPs with the presence of VC in CKD, insights in the underlying processes and mechanisms by which CPPs might aggravate VC and vascular dysfunction in vivo are currently lacking. Here, we assessed the overall burden of abdominal VC in healthy kidney donors and CKD patients and subsequently performed transcriptome profiling in the vascular tissue obtained from these subjects, linking outcome to CPP counts and calcification propensity.Methods and results
Calcification scores were quantified in renal arteries, iliac arteries, and abdomin","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-04-22T03:23:05.01Z","creation":"2025-04-06T17:29:50.249Z"},"accession":"S-EPMC11629976","cross_references":{"pubmed":["39102822"],"doi":["10.1093/cvr/cvae164"]}}