{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Beijing Hospital Management Center-Climb Plan","National Science Foundation of China","Youth Project of Beijing Natural Science Foundation","Capital Medical Science Innovation Center Scientific Research Pioneering Project","Young Scientists Program of Beijing Tiantan Hospital, Capital Medical University","National Natural Science Foundation of China","Ministry of Science and Technology of China-National Key Research Project","Capital Medical University Young Scholars"],"pagination":["1901-1909"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11630882"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(12)"],"pubmed_abstract":["<h4>Background and purpose</h4>The underlying transcriptomic signatures driving brain functional alterations in MS and neuromyelitis optica spectrum disorder (NMOSD) are still unclear.<h4>Materials and methods</h4>Regional fractional amplitude of low-frequency fluctuation (fALFF) values were obtained and compared among 209 patients with MS, 90 patients with antiaquaporin-4 antibody (AQP4)+ NMOSD, 49 with AQP4- NMOSD, and 228 healthy controls from a discovery cohort. We used partial least squares (PLS) regression to identify the gene transcriptomic signatures associated with disease-related fALFF alterations. The biologic process and cell type-specific signature of the identified PLS genes were explored by enrichment analysis. The correlation between PLS genes and clinical variables was exp"],"journal":["AJNR. American journal of neuroradiology"],"pubmed_title":["Imaging Transcriptomics of Brain Functional Alterations in MS and Neuromyelitis Optica Spectrum Disorder."],"pmcid":["PMC11630882"],"funding_grant_id":["2022YFC2009904","NO.7244328","822020840","DFL20220503","82330057","CX23YQ06","None","NO.YSP202205"],"pubmed_authors":["Li H","Zhuo Z","Zhang N","Han X","Tian D","Li K","Guo M","Liu Y","Li Y","Zhang X","Shi F","Zhou F","Xu X","Sun J","Duan Y"],"additional_accession":[]},"is_claimable":false,"name":"Imaging Transcriptomics of Brain Functional Alterations in MS and Neuromyelitis Optica Spectrum Disorder.","description":"<h4>Background and purpose</h4>The underlying transcriptomic signatures driving brain functional alterations in MS and neuromyelitis optica spectrum disorder (NMOSD) are still unclear.<h4>Materials and methods</h4>Regional fractional amplitude of low-frequency fluctuation (fALFF) values were obtained and compared among 209 patients with MS, 90 patients with antiaquaporin-4 antibody (AQP4)+ NMOSD, 49 with AQP4- NMOSD, and 228 healthy controls from a discovery cohort. We used partial least squares (PLS) regression to identify the gene transcriptomic signatures associated with disease-related fALFF alterations. The biologic process and cell type-specific signature of the identified PLS genes were explored by enrichment analysis. The correlation between PLS genes and clinical variables was exp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-05T20:57:29.598Z","creation":"2026-05-21T03:13:09.995Z"},"accession":"S-EPMC11630882","cross_references":{"pubmed":["39510804"],"doi":["10.3174/ajnr.A8480","10.3174/ajnr.a8480"]}}