{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ke ZH"],"funding":["The National Natural Science Foundation of China","The Zhejiang Provincial Medical and Health Science and Technology Plan"],"pagination":["e70486"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11632276"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(23)"],"pubmed_abstract":["<h4>Background</h4>Immune biomarkers for non-small-cell lung cancer (NSCLC) are programmed death ligand 1 (PD-L1) and tumor mutational burden (TMB). However, they cannot accurately predict the effectiveness of immunotherapy. Identifying appropriate biomarkers that can differentiate between beneficiary groups is imperative.<h4>Methods</h4>We identified lipoprotein receptor-related protein 1B (LRP1B) mutation as a potential biomarker for immunotherapy by analyzing clinical data, combined with bioinformatics analysis. The effects of LRP1B on ferroptosis were assessed using qRT-PCR, Western blotting, CCK-8 assay, and flow cytometry. The potential mechanism underlying the regulation of ferroptosis by LRP1B was elucidated using qRT-PCR, Western blotting, ChIP, and dual-luciferase reporter gene a"],"journal":["Cancer medicine"],"pubmed_title":["LRP1B Suppresses Immunotherapy Efficacy in Lung Adenocarcinoma by Preventing Ferroptosis."],"pmcid":["PMC11632276"],"funding_grant_id":["82172708","2024KY1517","82300230"],"pubmed_authors":["Lu KH","Xiang Y","Chen Y","Yu T","Ke ZH","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"LRP1B Suppresses Immunotherapy Efficacy in Lung Adenocarcinoma by Preventing Ferroptosis.","description":"<h4>Background</h4>Immune biomarkers for non-small-cell lung cancer (NSCLC) are programmed death ligand 1 (PD-L1) and tumor mutational burden (TMB). However, they cannot accurately predict the effectiveness of immunotherapy. Identifying appropriate biomarkers that can differentiate between beneficiary groups is imperative.<h4>Methods</h4>We identified lipoprotein receptor-related protein 1B (LRP1B) mutation as a potential biomarker for immunotherapy by analyzing clinical data, combined with bioinformatics analysis. The effects of LRP1B on ferroptosis were assessed using qRT-PCR, Western blotting, CCK-8 assay, and flow cytometry. The potential mechanism underlying the regulation of ferroptosis by LRP1B was elucidated using qRT-PCR, Western blotting, ChIP, and dual-luciferase reporter gene a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-26T16:07:47.171Z","creation":"2025-04-06T15:10:24.912Z"},"accession":"S-EPMC11632276","cross_references":{"pubmed":["39660409"],"doi":["10.1002/cam4.70486"]}}