{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yakubov S"],"funding":["Elitenetzwerk Bayern","Deutsche Forschungsgemeinschaft","Alexander von Humboldt-Stiftung"],"pagination":["e202401057"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11632574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(23)"],"pubmed_abstract":["Efficient fluorination reactions are key in the late-stage functionalization of complex molecules in medicinal chemistry, in upgrading chemical feedstocks, and in materials science. Radical C(sp<sup>3</sup>)-H fluorinations using Selectfluor<sup>®</sup> - one of the most popular fluorination agents - allow to directly engage unactivated precursors under mild photochemical or thermal catalytic conditions. However, H-TEDA(BF<sub>4</sub>)<sub>2</sub> to date is overlooked and discarded as waste, despite comprising 95% of the molecular weight of Selectfluor<sup>®</sup>. We demonstrate that the addition of H-TEDA(BF<sub>4</sub>)<sub>2</sub> at the start of fluorination reactions markedly promotes their rates and accesses higher overall yields of fluorinated products (~3.3 × higher on average ac"],"journal":["ChemSusChem"],"pubmed_title":["Protodefluorinated Selectfluor&lt;sup&gt;®&lt;/sup&gt; Aggregatively Activates Selectfluor&lt;sup&gt;®&lt;/sup&gt; for Efficient Radical C(sp&lt;sup&gt;3&lt;/sup&gt;)-H Fluorination Reactions."],"pmcid":["PMC11632574"],"funding_grant_id":["SynCat Master Programme","Sofja Kovalevskaja Award","426795949"],"pubmed_authors":["Stockerl WJ","Barham JP","Gschwind RM","Dauth B","da Silva W","Yakubov S"],"additional_accession":[]},"is_claimable":false,"name":"Protodefluorinated Selectfluor&lt;sup&gt;®&lt;/sup&gt; Aggregatively Activates Selectfluor&lt;sup&gt;®&lt;/sup&gt; for Efficient Radical C(sp&lt;sup&gt;3&lt;/sup&gt;)-H Fluorination Reactions.","description":"Efficient fluorination reactions are key in the late-stage functionalization of complex molecules in medicinal chemistry, in upgrading chemical feedstocks, and in materials science. Radical C(sp<sup>3</sup>)-H fluorinations using Selectfluor<sup>®</sup> - one of the most popular fluorination agents - allow to directly engage unactivated precursors under mild photochemical or thermal catalytic conditions. However, H-TEDA(BF<sub>4</sub>)<sub>2</sub> to date is overlooked and discarded as waste, despite comprising 95% of the molecular weight of Selectfluor<sup>®</sup>. We demonstrate that the addition of H-TEDA(BF<sub>4</sub>)<sub>2</sub> at the start of fluorination reactions markedly promotes their rates and accesses higher overall yields of fluorinated products (~3.3 × higher on average ac","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-22T13:14:58.743Z","creation":"2025-04-06T00:34:06.152Z"},"accession":"S-EPMC11632574","cross_references":{"pubmed":["38874542"],"doi":["10.1002/cssc.202401057"]}}