{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gosztyla ML"],"funding":["Natural Sciences and Engineering Research Council of Canada","Fonds de recherche du Quebec Sante","NSF","NIA NIH HHS","NIMH NIH HHS","Myotonic Dystrophy Foundation","NIH","Chan Zuckerberg Initiative","CIHR","NHGRI NIH HHS","NCI NIH HHS","Association for Women in Science","NIGMS NIH HHS","NIH HHS"],"pagination":["3826-3842.e8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11633308"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(19)"],"pubmed_abstract":["RNA interactome studies have revealed that hundreds of zinc-finger proteins (ZFPs) are candidate RNA-binding proteins (RBPs), yet their RNA substrates and functional significance remain largely uncharacterized. Here, we present a systematic multi-omics analysis of the DNA- and RNA-binding targets and regulatory roles of more than 100 ZFPs representing 37 zinc-finger families. We show that multiple ZFPs are previously unknown regulators of RNA splicing, alternative polyadenylation, stability, or translation. The examined ZFPs show widespread sequence-specific RNA binding and preferentially bind proximal to transcription start sites. Additionally, several ZFPs associate with their targets at both the DNA and RNA levels. We highlight ZNF277, a C2H2 ZFP that binds thousands of RNA targets and "],"journal":["Molecular cell"],"pubmed_title":["Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation."],"pmcid":["PMC11633308"],"funding_grant_id":["R35 GM142864","S10 OD025052","R01 HG004659","U41 HG009889","T32 CA067754","U24 HG011735","R01 HG012216","R01 HG011864","S10 OD026929","R01 AG071869","RF1 MH126719","U54 CA209891","U24 HG009889","P41 GM103504"],"pubmed_authors":["Gonzalez V","Jin W","Cavazos FF","Uddin Syed E","Goda GA","Jain M","Gosztyla ML","Olson S","Tankka AT","Dominguez D","Wei X","Kwon E","Yeo GW","Naritomi J","Nguyen G","Lecuyer E","Schmok JC","Street L","Jovanovic M","Graveley BR","Kofman E","Li A","Zhan L"],"additional_accession":[]},"is_claimable":false,"name":"Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation.","description":"RNA interactome studies have revealed that hundreds of zinc-finger proteins (ZFPs) are candidate RNA-binding proteins (RBPs), yet their RNA substrates and functional significance remain largely uncharacterized. Here, we present a systematic multi-omics analysis of the DNA- and RNA-binding targets and regulatory roles of more than 100 ZFPs representing 37 zinc-finger families. We show that multiple ZFPs are previously unknown regulators of RNA splicing, alternative polyadenylation, stability, or translation. The examined ZFPs show widespread sequence-specific RNA binding and preferentially bind proximal to transcription start sites. Additionally, several ZFPs associate with their targets at both the DNA and RNA levels. We highlight ZNF277, a C2H2 ZFP that binds thousands of RNA targets and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-03T05:10:56.777Z","creation":"2025-04-04T02:33:09.63Z"},"accession":"S-EPMC11633308","cross_references":{"pubmed":["39303722"],"doi":["10.1016/j.molcel.2024.08.010"]}}