{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Z"],"funding":["Shanghai Science and Technology Committee","Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China"],"pagination":["e2407517"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11633487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(46)"],"pubmed_abstract":["Tumor immune microenvironment is strongly associated with the malignancy behavior of hepatocellular carcinoma (HCC). However, the immune function and regulatory mechanisms of B cells in HCC remain unclear. The expression differences between B cell high- and low-infiltration HCC samples are explored to identify the key regulator. Pre-mRNA processing factor 19 (PRP19) expression is increased in B cell low-infiltrated tissues and negatively correlated with the B cell marker, CD20. Inhibition of PRP19 expression promoted B cell infiltration in tumor tissue and impeded HCC growth. Mechanically, the co-immunoprecipitation (Co-IP) assay revealed that PRP19 interacts with DEAD-box helicase 5 (DDX5), leading to ubiquitination and degradation of the DDX5 protein. The attenuated DDX5 impairs CXCL12 m"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Increased PRP19 in Hepatocyte Impedes B Cell Function to Promote Hepatocarcinogenesis."],"pmcid":["PMC11633487"],"funding_grant_id":["82203863","20Y11908100","82403314","82173122","82273027","81972234"],"pubmed_authors":["Zhang F","Liu Z","Zhang D","Xue R","Lin X","Dong L","Guo D","Tang W","Zhang S","Shen X","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"Increased PRP19 in Hepatocyte Impedes B Cell Function to Promote Hepatocarcinogenesis.","description":"Tumor immune microenvironment is strongly associated with the malignancy behavior of hepatocellular carcinoma (HCC). However, the immune function and regulatory mechanisms of B cells in HCC remain unclear. The expression differences between B cell high- and low-infiltration HCC samples are explored to identify the key regulator. Pre-mRNA processing factor 19 (PRP19) expression is increased in B cell low-infiltrated tissues and negatively correlated with the B cell marker, CD20. Inhibition of PRP19 expression promoted B cell infiltration in tumor tissue and impeded HCC growth. Mechanically, the co-immunoprecipitation (Co-IP) assay revealed that PRP19 interacts with DEAD-box helicase 5 (DDX5), leading to ubiquitination and degradation of the DDX5 protein. The attenuated DDX5 impairs CXCL12 m","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-02T11:17:45.929Z","creation":"2025-04-06T15:06:52.832Z"},"accession":"S-EPMC11633487","cross_references":{"pubmed":["39422063"],"doi":["10.1002/advs.202407517"]}}