{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou Z"],"funding":["National Natural Science Foundation of Distinguished Young Scholars","Jiangsu Provincial Key Laboratory of Critical Care Medicine","Natural Science Foundation Outstanding Youth Fund of Jiangsu Province","National Natural Science Foundation of China","Jiangsu provincial doctors of entrepreneurship and innovation","2030-Major Project of the Ministry of Science and Technology of China","Fundamental Research Funds for the Central Universities grant","Natural Science Foundation of Jiangsu Province"],"pagination":["e2404391"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11633488"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(46)"],"pubmed_abstract":["Astrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision-tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ischemic stroke. Microdomain calcium (Ca<sup>2+</sup>) transients in astrocytic processes are pivotal for the functional regulation of these processes. However, the understanding of the alterations and regulatory mechanism of microdomain Ca<sup>2+</sup> transients during stroke remains limited. In the present study, a fast high-resolution, miniaturized two-photon microscopy is used to show that the levels of astrocytic microdomain Ca<sup>2+</sup> transients are significantly reduced in the peri-infarct area of awake ischemic stroke mice. This"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Membrane Associated RNA-Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice."],"pmcid":["PMC11633488"],"funding_grant_id":["82230115","(2020)30293","82003733","82473903","82273914","2242024RCB0026","BK20200358","2242022R40059","81903591","2021ZD0202904","JSKLCCM-2022-02-008","82025033"],"pubmed_authors":["Xi W","Shen L","Gu X","Luo Z","Bai Y","Zhou Z","Ren H","Liu X","Han B","Bian L","Huang W","Xiang X","Wang Y","Yao H"],"additional_accession":[]},"is_claimable":false,"name":"Membrane Associated RNA-Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice.","description":"Astrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision-tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ischemic stroke. Microdomain calcium (Ca<sup>2+</sup>) transients in astrocytic processes are pivotal for the functional regulation of these processes. However, the understanding of the alterations and regulatory mechanism of microdomain Ca<sup>2+</sup> transients during stroke remains limited. In the present study, a fast high-resolution, miniaturized two-photon microscopy is used to show that the levels of astrocytic microdomain Ca<sup>2+</sup> transients are significantly reduced in the peri-infarct area of awake ischemic stroke mice. This","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-03T00:54:53.851Z","creation":"2025-04-06T15:08:21.611Z"},"accession":"S-EPMC11633488","cross_references":{"pubmed":["39444078"],"doi":["10.1002/advs.202404391"]}}