{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(50)"],"submitter":["Sarkar A"],"pubmed_abstract":["A method is presented for high-precision chemical detection that integrates quantum sensing with droplet microfluidics. Using nanodiamonds (ND) with fluorescent nitrogen-vacancy (NV) centers as quantum sensors, rapidly flowing microdroplets containing analyte molecules are analyzed. A noise-suppressed mode of optically detected magnetic resonance is enabled by pairing controllable flow with microwave control of NV electronic spins, to detect analyte-induced signals of a few hundredths of a percent of the ND fluorescence. Using this method, paramagnetic ions in droplets are detected with low limit-of-detection using small analyte volumes, with exceptional measurement stability over >10<sup>3</sup> s. In addition, these droplets are used as microconfinement chambers by co-encapsulating ND quantum sensors with various analytes such as single cells, suggesting wide-ranging applications including single-cell metabolomics and real-time intracellular measurements from bioreactors. Important advances are enabled by this work, including portable chemical testing devices, amplification-free chemical assays, and chemical imaging tools for probing reactions within microenvironments."],"journal":["Science advances"],"pagination":["eadp4033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11633744"],"repository":["biostudies-literature"],"pubmed_title":["High-precision chemical quantum sensing in flowing monodisperse microdroplets."],"pmcid":["PMC11633744"],"pubmed_authors":["Ajoy A","Sarkar A","Jones ZR","Conti S","Wilson KR","Gilbert B","Krishnamoorthi P","Nunn N","Aman P","Torelli MD","Nachuri S","Shenderova OA","Druga E","Hashemi M","Tanjore D","Parashar M","Akkiraju A"],"additional_accession":[]},"is_claimable":false,"name":"High-precision chemical quantum sensing in flowing monodisperse microdroplets.","description":"A method is presented for high-precision chemical detection that integrates quantum sensing with droplet microfluidics. Using nanodiamonds (ND) with fluorescent nitrogen-vacancy (NV) centers as quantum sensors, rapidly flowing microdroplets containing analyte molecules are analyzed. A noise-suppressed mode of optically detected magnetic resonance is enabled by pairing controllable flow with microwave control of NV electronic spins, to detect analyte-induced signals of a few hundredths of a percent of the ND fluorescence. Using this method, paramagnetic ions in droplets are detected with low limit-of-detection using small analyte volumes, with exceptional measurement stability over >10<sup>3</sup> s. In addition, these droplets are used as microconfinement chambers by co-encapsulating ND quantum sensors with various analytes such as single cells, suggesting wide-ranging applications including single-cell metabolomics and real-time intracellular measurements from bioreactors. Important advances are enabled by this work, including portable chemical testing devices, amplification-free chemical assays, and chemical imaging tools for probing reactions within microenvironments.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T02:33:07.474Z","creation":"2025-04-04T02:33:07.474Z"},"accession":"S-EPMC11633744","cross_references":{"pubmed":["39661672"],"doi":["10.1126/sciadv.adp4033"]}}