{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["112"],"submitter":["Yamakawa R"],"pubmed_abstract":["Hydrogel-based drug carriers provide on-demand drug release via external stimuli. Ultrasound is a promising method because of the potential for remotely releasing the drug. However, intense ultrasound irradiation has been required in previous studies. This paper reports drug model release from hydrogel carriers encapsulating bubble vibration enhancers (BVEs) consisting of microbubbles coated with a lipid membrane. Vibration of BVEs induced by ultrasound stimulation promoted the release of drug models with ultrasound irradiation controlled to a biologically safe acoustic pressure based on spatial-peak temporal-average intensity (I<sub>SPTA</sub>). The release ratio increased significantly from 2.3 % without BVEs and ultrasound to 10.2 % with both. To evaluate the frequency response, the rel"],"journal":["Ultrasonics sonochemistry"],"pagination":["107173"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11635015"],"repository":["biostudies-literature"],"pubmed_title":["Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release."],"pmcid":["PMC11635015"],"pubmed_authors":["Yamakawa R","Kurashina Y","Onoe H"],"additional_accession":[]},"is_claimable":false,"name":"Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release.","description":"Hydrogel-based drug carriers provide on-demand drug release via external stimuli. Ultrasound is a promising method because of the potential for remotely releasing the drug. However, intense ultrasound irradiation has been required in previous studies. This paper reports drug model release from hydrogel carriers encapsulating bubble vibration enhancers (BVEs) consisting of microbubbles coated with a lipid membrane. Vibration of BVEs induced by ultrasound stimulation promoted the release of drug models with ultrasound irradiation controlled to a biologically safe acoustic pressure based on spatial-peak temporal-average intensity (I<sub>SPTA</sub>). The release ratio increased significantly from 2.3 % without BVEs and ultrasound to 10.2 % with both. To evaluate the frequency response, the rel","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-26T16:20:28.093Z","creation":"2025-04-06T15:07:53.184Z"},"accession":"S-EPMC11635015","cross_references":{"pubmed":["39612755"],"doi":["10.1016/j.ultsonch.2024.107173"]}}