biostudies-literatureUnknown26Sato A<h4>Background</h4>Hereditary breast and ovarian cancer (HBOC) is a major type of hereditary cancer. Establishing effective screening to identify high-risk individuals for HBOC remains a challenge. We developed a prototype of a chatbot system that uses artificial intelligence (AI) for preliminary HBOC screening to determine whether individuals meet the National Comprehensive Cancer Network BRCA1/2 testing criteria.<h4>Objective</h4>This study's objective was to validate the feasibility of this chatbot in a clinical setting by using it on a patient population that visited a hospital.<h4>Methods</h4>We validated the medical accuracy of the chatbot system by performing a test on patients who consecutively visited the Kanagawa Cancer Center. The participants completed a preoperation questionnaJournal of medical Internet researche48914https://www.ebi.ac.uk/biostudies/studies/S-EPMC11635313biostudies-literaturePreliminary Screening for Hereditary Breast and Ovarian Cancer Using an AI Chatbot as a Genetic Counselor: Clinical Study.PMC11635313Sato AHaneda ENarimatsu HHiroshima YfalsePreliminary Screening for Hereditary Breast and Ovarian Cancer Using an AI Chatbot as a Genetic Counselor: Clinical Study.<h4>Background</h4>Hereditary breast and ovarian cancer (HBOC) is a major type of hereditary cancer. Establishing effective screening to identify high-risk individuals for HBOC remains a challenge. We developed a prototype of a chatbot system that uses artificial intelligence (AI) for preliminary HBOC screening to determine whether individuals meet the National Comprehensive Cancer Network BRCA1/2 testing criteria.<h4>Objective</h4>This study's objective was to validate the feasibility of this chatbot in a clinical setting by using it on a patient population that visited a hospital.<h4>Methods</h4>We validated the medical accuracy of the chatbot system by performing a test on patients who consecutively visited the Kanagawa Cancer Center. The participants completed a preoperation questionna2024-01-01T00:00:00Z2024 Nov2025-04-03T23:26:10.957Z2025-04-03T23:26:10.957ZS-EPMC116353133960280110.2196/48914