{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["112"],"submitter":["Yang G"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["The hypoxic and immunosuppressive tumor microenvironment (TME) remains a major obstacle to impede cancer immunotherapy. Here, we found that sononeoperfusion-a new effect of tumor perfusion enhancement induced by low mechanical index ultrasound stimulated microbubble cavitation (USMC)-ameliorated tumor tissue oxygenation and induced tumor vascular normalization (TVN). This TVN might be associated with the down-regulation of hypoxia-inducible factor 1-alpha (HIF-1α) and vascular endothelial growth factor (VEGF) within tumors. Moreover, the sononeoperfusion effect reduced the accumulation of immunosuppressive cells, such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs) and M2-like tumor-associated macrophages (M2-TAMs), and decreased the production of immune inhibitory "],"journal":["Ultrasonics sonochemistry"],"pagination":["107115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11635779"],"repository":["biostudies-literature"],"pubmed_title":["Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: A New Ally for potentiating anti-PD-L1 blockade of solid Tumor."],"pmcid":["PMC11635779"],"pubmed_authors":["Yao L","Zhou M","Yang G","Li H","Yang J","Zhang J","Dong X","Li N","Yang X","Tang J","Liu Z","Zhang Y","Wu Y","Yin J","Luo T"],"additional_accession":[]},"is_claimable":false,"name":"Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: A New Ally for potentiating anti-PD-L1 blockade of solid Tumor.","description":"The hypoxic and immunosuppressive tumor microenvironment (TME) remains a major obstacle to impede cancer immunotherapy. Here, we found that sononeoperfusion-a new effect of tumor perfusion enhancement induced by low mechanical index ultrasound stimulated microbubble cavitation (USMC)-ameliorated tumor tissue oxygenation and induced tumor vascular normalization (TVN). This TVN might be associated with the down-regulation of hypoxia-inducible factor 1-alpha (HIF-1α) and vascular endothelial growth factor (VEGF) within tumors. Moreover, the sononeoperfusion effect reduced the accumulation of immunosuppressive cells, such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs) and M2-like tumor-associated macrophages (M2-TAMs), and decreased the production of immune inhibitory ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-22T13:09:05.656Z","creation":"2025-04-06T00:35:39.617Z"},"accession":"S-EPMC11635779","cross_references":{"pubmed":["39482116"],"doi":["10.1016/j.ultsonch.2024.107115"]}}