{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wong KLL"],"funding":["Temasek Life Sciences Laboratory","Singapore Ministry of Education"],"pagination":["1980"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11640313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(23)"],"pubmed_abstract":["The claustrum is a small but densely interconnected brain structure that is innervated by axons containing serotonin (5-HT), a neuromodulator that has been implicated in control of sleep and in the actions of psychedelic drugs. However, little is known about how 5-HT influences the claustrum. We have combined whole-cell patch-clamp measurements of ionic currents, flash photolysis, and receptor pharmacology to characterize the 5-HT responses of individual claustral projection neurons (PNs) in mouse brain slices. Serotonin application elicited a long-lasting outward current in claustral PNs. This current was due to an increase in membrane permeability to K<sup>+</sup> ions and was mediated mainly by the type 1A 5-HT receptor (5-HTR-1A). The 5-HT-induced K<sup>+</sup> current hyperpolarized, "],"journal":["Cells"],"pubmed_title":["Serotonin Inhibition of Claustrum Projection Neurons: Ionic Mechanism, Receptor Subtypes and Consequences for Claustrum Computation."],"pmcid":["PMC11640313"],"funding_grant_id":["0","MOE2017-T3-1-002"],"pubmed_authors":["Graf M","Augustine GJ","Wong KLL"],"additional_accession":[]},"is_claimable":false,"name":"Serotonin Inhibition of Claustrum Projection Neurons: Ionic Mechanism, Receptor Subtypes and Consequences for Claustrum Computation.","description":"The claustrum is a small but densely interconnected brain structure that is innervated by axons containing serotonin (5-HT), a neuromodulator that has been implicated in control of sleep and in the actions of psychedelic drugs. However, little is known about how 5-HT influences the claustrum. We have combined whole-cell patch-clamp measurements of ionic currents, flash photolysis, and receptor pharmacology to characterize the 5-HT responses of individual claustral projection neurons (PNs) in mouse brain slices. Serotonin application elicited a long-lasting outward current in claustral PNs. This current was due to an increase in membrane permeability to K<sup>+</sup> ions and was mediated mainly by the type 1A 5-HT receptor (5-HTR-1A). The 5-HT-induced K<sup>+</sup> current hyperpolarized, ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T01:36:05.925Z","creation":"2025-04-04T01:36:05.925Z"},"accession":"S-EPMC11640313","cross_references":{"pubmed":["39682728"],"doi":["10.3390/cells13231980"]}}