biostudies-literatureUnknown14(23)Tran DD<b>Background</b>: Cardiomyopathy, including dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), is a major cause of heart failure (HF) and a leading indication for heart transplantation. Of these patients, 20-50% have a genetic cause, so understanding the genetic basis of cardiomyopathy will provide knowledge about the pathogenesis of the disease for diagnosis, treatment, prevention, and genetic counseling for families. <b>Methods</b>: This study collected nine patients from different Vietnamese families for genetic analysis at The Cardiovascular Center, E Hospital, Hanoi, Vietnam. The patients were diagnosed with cardiomyopathy based on clinical symptoms. Whole-exome sequencing (WES) was performed in the Vietnamese patients to identify variants associated with cardiomyopaDiagnostics (Basel, Switzerland)2709https://www.ebi.ac.uk/biostudies/studies/S-EPMC11640685biostudies-literatureThree Novel Pathogenic Variants in Unrelated Vietnamese Patients with Cardiomyopathy.PMC11640685Oanh TTKTung NVTien DAHuy BQTran DDDuc NMHoang NHHuu NCLien NTPThanh LTHien NTLien NTKNguyen PTThu DTHLan NNfalseThree Novel Pathogenic Variants in Unrelated Vietnamese Patients with Cardiomyopathy.<b>Background</b>: Cardiomyopathy, including dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), is a major cause of heart failure (HF) and a leading indication for heart transplantation. Of these patients, 20-50% have a genetic cause, so understanding the genetic basis of cardiomyopathy will provide knowledge about the pathogenesis of the disease for diagnosis, treatment, prevention, and genetic counseling for families. <b>Methods</b>: This study collected nine patients from different Vietnamese families for genetic analysis at The Cardiovascular Center, E Hospital, Hanoi, Vietnam. The patients were diagnosed with cardiomyopathy based on clinical symptoms. Whole-exome sequencing (WES) was performed in the Vietnamese patients to identify variants associated with cardiomyopa2024-01-01T00:00:00Z2024 Nov2026-05-26T20:09:55.433Z2025-04-06T22:30:07.658ZS-EPMC116406853968261710.3390/diagnostics14232709